0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Effects of Some Opiates and Opioid Peptide Eyedrops on Ocular Melatonin Regulation in Rabbits

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Levels of melatonin in rabbit eye tissues were detected by radioimmunoassay. Solutions of met-enkephalin, leu-enkephalin, α-endorphin and β-endorphin were given topically. Met-Enkephalin and α-endorphin lowered levels of melatonin in the iris, iris root-ciliary body, retina and choroid; leu-enkephalin raised levels in the retina and lowered them in other tissues. β-Endorphin only lowered levels in the iris root-ciliary body. DAGO (a μ agonist) given i.v. lowered levels of melatonin in the iris, iris root-ciliary body and retina. The δ and σ agonists given i.v. only lowered levels in the iris root-ciliary body, and a k agonist given i.v. raised levels in the ciliary body. No opiate binding sites could be detected in the rabbit iris or iris root-ciliay body for any class of receptor. Our data suggest opioids may be useful for treating glaucoma.

          Related collections

          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1993
          1993
          11 December 2009
          : 25
          : 6
          : 378-385
          Affiliations
          Institute of Ocular Pharmacology and Department of Medical Pharmacology and Toxicology, TAMU College of Medicine, College Station, Tex., USA
          Article
          267340 Ophthalmic Res 1993;25:378–385
          10.1159/000267340
          8309677
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Original Paper

          Comments

          Comment on this article