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      Evaluation of Prader-Willi Syndrome gene MAGEL2 in severe childhood-onset obesity.

      1 , ,
      Obesity research
      Springer Nature America, Inc

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          Abstract

          MAGEL2 is one of the five genes inactivated in Prader-Willi Syndrome, a neurodevelopmental chromosome microdeletion disorder modified by genomic imprinting. By early childhood, individuals with Prader-Willi Syndrome exhibit hypothalamic dysfunction, including hyperphagia, and become obese in the absence of behavioral intervention. Murine Magel2 is highly expressed in the hypothalamus during development. We screened the MAGEL2 open reading frame for mutations in genomic DNA samples from hyperphagic but non-dysmorphic individuals with severe childhood-onset obesity. Although no mutations likely to affect gene function were identified, we identified three variant alleles. We conclude that severe childhood-onset obesity is not commonly caused by MAGEL2 mutations.

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          Author and article information

          Journal
          Obes. Res.
          Obesity research
          Springer Nature America, Inc
          1071-7323
          1071-7323
          Oct 2005
          : 13
          : 10
          Affiliations
          [1 ] Department of Medical Genetics, 8-42 Medical Science Building, University of Alberta, Edmonton, Alberta, Canada T6G 2H7.
          Article
          13/10/1841
          10.1038/oby.2005.224
          16286533
          b55055e2-4a19-48cf-880d-ecebe7a67870

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