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      Tenofovir-associated bone density loss

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          Abstract

          Clinical observations have revealed a strong correlation between loss of bone density in HIV-infected individuals, particularly in conjunction with the antiretroviral drug tenofovir, a nucleotide analog that inhibits HIV reverse transcriptase. The most compelling correlations have been observed in clinical studies involving young children and adolescents. These observations strongly suggest that bone density is being affected during active bone growth and development, implicating a role for tenofovir in bone loss. Here we discuss the literature and potential mechanisms for how tenofovir-associated bone loss may arise, which likely involves perturbation of cellular DNA synthesis and gene expression. Elucidation of the mechanism(s) involved in tenofovir-mediated bone loss will help in developing adjuvant therapies to reduce tenofovir-associated bone density loss.

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          Author and article information

          Journal
          Ther Clin Risk Manag
          Therapeutics and Clinical Risk Management
          Therapeutics and Clinical Risk Management
          Dove Medical Press
          1176-6336
          1178-203X
          2010
          2010
          2 February 2010
          : 6
          : 41-47
          Affiliations
          [1 ]Division of Orthodontics
          [2 ]Department of Developmental and Surgical Sciences
          [3 ]Department of Diagnostic and Biological Sciences
          [4 ]MinnCResT Program, School of Dentistry and
          [5 ]Institute for Molecular Virology, Academic Health Center, University of Minnesota, Minneapolis, MN, USA
          Author notes
          Correspondence: Kim C Mansky, University of Minnesota, 16-146 Moos Tower, 515 Delaware St. SE, Minneapolis, MN 55455, USA, Tel +1 612-626-5582, Fax +1 612-626-5515, Email kmansky@ 123456umn.edu
          Article
          tcrm-6-041
          2817787
          20169035
          © 2010 Grigsby et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          Categories
          Mini – Review

          Medicine

          tenofovir, osteoblast, dysfunction, renal, osteoclast, pmpa

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