TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology

Abstract

The transforming growth factor-β (TGF-β) is the prototype of the TGF-β family of growth and differentiation factors, which is encoded by 33 genes in mammals and comprises homo- and heterodimers. This review introduces the reader to the TGF-β family with its complexity of names and biological activities. It also introduces TGF-β as the best-studied factor among the TGF-β family proteins, with its diversity of roles in the control of cell proliferation and differentiation, wound healing and immune system, and its key roles in pathology, for example, skeletal diseases, fibrosis, and cancer.

Abstract

Members of the TGF-β family are encoded by 33 genes in mammals and show diverse roles in health and disease. Their effects are contextual; a cell may show differing or opposing responses to them, depending on the situation.