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      High Clinical Burden of Influenza Disease in Adults Aged ≥ 65 Years: Can We Do Better? A Systematic Literature Review.

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          Abstract

          Influenza is a respiratory infection associated with a significant clinical burden globally. Adults aged ≥ 65 years are at increased risk of severe influenza-related symptoms and complications due to chronic comorbidity and immunosenescence. Annual influenza vaccination is recommended; however, current influenza vaccines confer suboptimal protection, in part due to antigen mismatch and poor durability. This systematic literature review characterizes the global clinical burden of seasonal influenza among adults aged ≥ 65 years.

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          Author and article information

          Journal
          Adv Ther
          Advances in therapy
          Springer Science and Business Media LLC
          1865-8652
          0741-238X
          Apr 2023
          : 40
          : 4
          Affiliations
          [1 ] Pfizer Patient & Health Impact, Pfizer Portugal, Lagoas Park, Edifício 10, 2740-271, Porto Salvo, Portugal. Jakob.Langer@pfizer.com.
          [2 ] Pfizer Vaccines Medical & Scientific Affairs, Collegeville, PA, USA.
          [3 ] Pfizer Emerging Markets, Vaccines Medical & Scientific Affairs, Cambridge, MA, USA.
          [4 ] Adelphi Values PROVE, Bollington, SK10 5JB, UK.
          Article
          10.1007/s12325-023-02432-1
          10.1007/s12325-023-02432-1
          9930064
          36790682
          b574190f-1b4d-4ef1-b264-2887bbec79ce
          History

          mRNA vaccine,Vaccination,Strain,Older adults,Mortality,Hospitalization,Burden of disease

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