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      A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States.

      Expert Review of Clinical Pharmacology

      Acetaminophen, administration & dosage, therapeutic use, toxicity, Analgesics, Non-Narcotic, Analgesics, Opioid, Dose-Response Relationship, Drug, Drug Overdose, Drug Synergism, Drug Therapy, Combination, Drug-Induced Liver Injury, epidemiology, etiology, Humans, Kidney Diseases, chemically induced, Risk Factors, United States

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          Abstract

          Acetaminophen is a commonly-used analgesic in the US and, at doses of more than 4 g/day, can lead to serious hepatotoxicity. Recent FDA and CMS decisions serve to limit and monitor exposure to high-dose acetaminophen. This literature review aims to describe the exposure to and consequences of high-dose acetaminophen among chronic pain patients in the US. Each year in the US, approximately 6% of adults are prescribed acetaminophen doses of more than 4 g/day and 30,000 patients are hospitalized for acetaminophen toxicity. Up to half of acetaminophen overdoses are unintentional, largely related to opioid-acetaminophen combinations and attempts to achieve better symptom relief. Liver injury occurs in 17% of adults with unintentional acetaminophen overdose.

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          Journal
          24678654
          10.1586/17512433.2014.904744

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