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      Acarbose is a competitive inhibitor of mammalian lysosomal acid alpha-D-glucosidases.

      1 ,
      Carbohydrate research

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          Abstract

          Intraperitoneal injections (approximately 400 mg/kg of body weight) of acarbose, an inhibitor of acid (1----4)-alpha-D-glucosidase, perturb the metabolism of glycogen in the liver, resulting in excess storage of lysosomal glycogen. The metabolism of skeletal muscle glycogen was unaffected, suggesting that acarbose either does not enter the tissue or that the muscle alpha-D-glucosidase is not inhibited. The hydrolysis of maltose and glycogen by the acid alpha-D-glucosidases from rat liver, rat skeletal muscle, and human placenta was inhibited competitively by acarbose. Thus, the lack of effect of acarbose upon the metabolism of muscle glycogen is due to its inability to enter the tissue.

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          Author and article information

          Journal
          Carbohydr. Res.
          Carbohydrate research
          0008-6215
          0008-6215
          Aug 1 1989
          : 191
          : 1
          Affiliations
          [1 ] Department of Biochemistry, University of Auckland, New Zealand.
          Article
          0008-6215(89)85047-5
          2776140
          b57b4dd7-6865-4e3f-934a-8e9ee6893fd4
          History

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