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      Escin, a natural mixture of triterpene saponins, exhibits antitumor activity against hepatocellular carcinoma.

      Planta medica
      Aesculus, chemistry, Animals, Antineoplastic Agents, Phytogenic, pharmacology, therapeutic use, Apoptosis, drug effects, Carcinoma, Hepatocellular, drug therapy, Cell Cycle, Cell Line, Tumor, Cell Survival, Dose-Response Relationship, Drug, Escin, Female, Hep G2 Cells, Humans, Liver Neoplasms, Mice, Mice, Inbred Strains, Phytotherapy, Plant Extracts, Xenograft Model Antitumor Assays

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          Abstract

          Escin, a mixture of triterpene saponins extracted from Aesculus wilsonii Rehd., was used to analyze the antitumor effect in hepatocellular carcinoma in vivo and in vitro. At a dose of 2.8 mg/kg, escin had a rather high inhibition ratio (43.5 %) on mice H22 tumor growth in vivo. The results of the SRB cell viability assay showed that escin could induce significant concentration- and time-dependent inhibition of HepG (2) cell viability. Disruption of the G (1)/S phase of cell cycle progression accompanied by the induction of apoptosis were also observed in HepG (2) cells following escin treatment. The results of pulse-field gel electrophoresis and Western blot analysis show the induction of caspase-independent apoptosis by escin. This study provides evidence that escin induces cell cycle checkpoint arrest and caspase-independent cell death in HepG (2) cells, in support of its efficacious potential as a chemopreventive agent. Georg Thieme Verlag KG Stuttgart. New York.

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