Blog
About

49
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Impact of Reduced Heart Rate Variability on Risk for Cardiac Events : The Framingham Heart Study

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Although heart rate variability (HRV) is altered in a variety of pathological conditions, the association of reduced HRV with risk for new cardiac events has not been studied in a large community-based population. The first 2 hours of ambulatory ECG recordings obtained on subjects of the Framingham Heart Study who were free of clinically apparent coronary heart disease or congestive heart failure were reprocessed to assess HRV. Five frequency-domain measures and three time-domain measures were obtained. The associations between HRV measures and the incidence of new cardiac events (angina pectroris, myocardial infarction, coronary heart disease death, or congestive heart failure) were assessed with proportional hazards regression analyses. There were 2501 eligible subjects with a mean age of 53 years. During a mean follow-up of 3.5 years, cardiac events occurred in 58 subjects. After adjustment for age, sex, cigarette smoking, diabetes, left ventricular hypertrophy, and other relevant risk factors, all HRV measures except the ratio of low-frequency to high-frequency power were significantly associated with risk for a cardiac event (P = .0016 to .0496). A one-standard deviation decrement in the standard deviation of total normal RR intervals (natural log transformed) was associated with a hazard ratio of 1.47 for new cardiac events (95% confidence interval of 1.16 to 1.86). The estimation of HRV by ambulatory monitoring offers prognostic information beyond that provided by the evaluation of traditional cardiovascular disease risk factors.

          Related collections

          Most cited references 16

          • Record: found
          • Abstract: not found
          • Article: not found

          Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis.

            Neurohumoral modulation of cardiovascular function is an important component of the hemodynamic alterations in patients with chronic congestive heart failure (CHF). Analysis of heart rate (HR) variability is a noninvasive means of investigating the autonomic control of the heart. The variability of HR and respiratory signals, both derived from ambulatory electrocardiographic recordings, were analyzed with power spectral analysis to evaluate autonomic control in 25 patients with chronic stable CHF (class III or IV) and 21 normal control subjects. In the patients with CHF, HR spectral power was markedly reduced (p less than 0.0001) at all frequencies examined (0.01 to 1.0 Hz, period 1 to 100 seconds) and virtually absent at frequencies greater than 0.04 Hz. Heart rate fluctuations at very low frequencies (0.01 to 0.04 Hz) less effectively differentiated CHF patients from control subjects, due to discrete (about 65 seconds, 0.015 Hz) oscillation in HR, which was associated with a similar pattern in respiratory activity in many of the patients with CHF. These findings demonstrate a marked derangement of HR modulation in patients with severe CHF. The frequency characteristics of HR fluctuations in these patients are consistent with abnormal baroreflex responsiveness to physiologic stimuli, and suggest that there is diminished vagal, but relatively preserved sympathetic, modulation of HR.
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              AN APPROACH TO LONGITUDINAL STUDIES IN A COMMUNITY: THE FRAMINGHAM STUDY

                Bookmark

                Author and article information

                Journal
                Circulation
                Circulation
                Ovid Technologies (Wolters Kluwer Health)
                0009-7322
                1524-4539
                December 1996
                December 1996
                : 94
                : 11
                : 2850-2855
                Affiliations
                [1 ]Kansai Medical University (H.T.), Osaka, Japan; Lahey Clinic Medical Center (F.J.V.), Burlington, Mass; Framingham Heart Study (H.T., M.G.L., E.S.M., J.C.E., D.L.), Framingham, Mass; National Heart, Lung, and Blood Institute (D.L.), Bethesda, Md; Brigham and Women's Hospital (C.L.F.), Boston, Mass; the Divisions of Cardiology and Clinical Epidemiology of Beth Israel Hospital (D.L.), Boston, Mass; and the Divisions of Epidemiology and Preventive Medicine of Boston University School of Medicine (D.L.)...
                Article
                10.1161/01.CIR.94.11.2850
                8941112
                © 1996

                Comments

                Comment on this article