Ovarian Hyperstimulation Syndrome in Voluntary Ovum Donors: A Case Series

ABSTRACT

Aim

The aim of this study was to report a case series of ovarian hyperstimulation syndrome in voluntary oocyte donors and discuss their management and clinical course.

Background

Ovarian hyperstimulation syndrome is a rare, iatrogenic complication occurring in artificial reproductive technology cycles. Recently, with the boost in the use of oocyte donors in ART, it has been noted that voluntary oocyte donors who undergo controlled ovarian hyperstimulation to induce superovulation in them are increasingly suffering from this syndrome. This syndrome varies from mild-to-severe and may become potentially lethal, the pathophysiologic hallmark of which is the accumulation of massive extravascular exudate combined with profound intravascular volume depletion.

Case description

Seven voluntary oocyte donors who have undergone multiple cycles of superovulation and oocyte retrieval presented with moderate-to-severe ovarian hyperstimulation syndrome (OHSS) and required admission. Clinical examination and ultrasonography confirmed the diagnosis of ovarian hyperstimulation syndrome. Most of these patients were optimally managed by conservative methods while two developed complications and required emergency laparotomy.

Clinical significance

With proper precautions and early detection, the deleterious effects of this condition can be prevented, and progression to a life-threatening ailment can be avoided. Donors must be thoroughly investigated and their donations must be well-spaced to avoid these negative impacts on their health. Understanding this condition will allow better management of donors at ART centers and prompt recognition of such complications by the clinician.

How to cite this article

Bhosale AA, Mahapatra S, Nayak AH, et al. Ovarian Hyperstimulation Syndrome in Voluntary Ovum Donors: A Case Series. J South Asian Feder Obst Gynae 2023;15(3):368–371.