1,358
views
0
recommends
+1 Recommend
0 collections
    8
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences

      Journal of Molecular Evolution

      Springer Science and Business Media LLC

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Some simple formulae were obtained which enable us to estimate evolutionary distances in terms of the number of nucleotide substitutions (and, also, the evolutionary rates when the divergence times are known). In comparing a pair of nucleotide sequences, we distinguish two types of differences; if homologous sites are occupied by different nucleotide bases but both are purines or both pyrimidines, the difference is called type I (or "transition" type), while, if one of the two is a purine and the other is a pyrimidine, the difference is called type II (or "transversion" type). Letting P and Q be respectively the fractions of nucleotide sites showing type I and type II differences between two sequences compared, then the evolutionary distance per site is K = -(1/2) ln [(1-2P-Q) square root of 1-2Q]. The evolutionary rate per year is then given by k = K/(2T), where T is the time since the divergence of the two sequences. If only the third codon positions are compared, the synonymous component of the evolutionary base substitutions per site is estimated by K'S = -(1/2) ln (1-2P-Q). Also, formulae for standard errors were obtained. Some examples were worked out using reported globin sequences to show that synonymous substitutions occur at much higher rates than amino acid-altering substitutions in evolution.

          Related collections

          Most cited references 15

          • Record: found
          • Abstract: not found
          • Article: not found

          The neutral theory of molecular evolution.

           M. Kimura (1979)
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Non-Darwinian Evolution

             J King,  T JUKES (1969)
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution.

               M. Kimura (1977)
                Bookmark

                Author and article information

                Journal
                Journal of Molecular Evolution
                J Mol Evol
                Springer Science and Business Media LLC
                0022-2844
                1432-1432
                June 1980
                June 1980
                : 16
                : 2
                : 111-120
                Article
                10.1007/BF01731581
                7463489
                © 1980

                Comments

                Comment on this article