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      Effects of Uremic Plasma on α- and β-Adrenoceptor Subtypes

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          Responsiveness of adrenergic receptors is decreased in patients on maintenance hemodialysis. In this study we investigated whether uremic plasma might affect adrenergic receptors. For this purpose we determined the effects of uremic plasma obtained from 10 patients on hemodialysis treatment (mean age 61 ± 3 years, dialysis frequency 3 × 4 h/week, duration of treatment 3 ± 1 years) before and at the end of the 4-hour dialysis treatment on binding of radioligands to β<sub>1</sub>- and β<sub>2</sub>- as well as α<sub>1</sub>- and α<sub>2</sub>-adrenoceptors. Plasma from 6 healthy volunteers served as control; the plasmas were studied in three dilutions: undiluted, 1:1 (v/v) and 1:4 (v/v) with saline diluted. Plasma from healthy control did not significantly affect the number of β<sub>1</sub>- and β<sub>2</sub>- or α<sub>1</sub>- and α<sub>2</sub>-adrenoceptors. On the other hand, uremic plasma significantly decreased the number of β<sub>1</sub>- and β<sub>2</sub>-adrenoceptors; this inhibitory effect was also observed when plasma obtained at the end of the 4-hour dialysis treatment was investigated. On the other hand, uremic plasma did not significantly decrease the number of α<sub>1</sub>- and α<sub>2</sub>-adrenoceptors. We conclude that in patients on maintenance hemodialysis, the presence of inhibitory substance(s) in uremic plasma could be – at least partly – responsible for the β-adrenoceptor hyporesponsiveness; the mechanism leading ot α-adrenoceptor hyporesponsiveness, however, remains to be elucidated.

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          Effect of chronic uremia on the cardiovascular alpha 1 receptor.

          Adrenergic dysfunction in uremia has been well described. Several lines of evidence suggest disorders of blood pressure regulation and myocardial response may occur secondary to adrenergic dysfunction; attenuated pressor response to norepinephrine (NE) in uremia; attenuated chronotropic responses during dialysis induced hypotension. Since the adrenergic receptors are the effector component of the adrenergic nervous system, we have employed the partially nephrectomized uremic rat, to examine the effect of chronic uremia (4-6 weeks) on the binding properties of alpha 1 receptors in rat mesenteric artery and myocardial tissue. The results indicate that moderate levels of uremia alter the binding properties of both the alpha 1 vascular and myocardial receptor.
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            Correlation between human myometrial and platelet α2-adrenoceptor density

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              Selective labelling of β1-adrenoceptors in rabbit lung membranes by (−)[3H]bisoprolol


                Author and article information

                S. Karger AG
                September 1998
                04 September 1998
                : 80
                : 1
                : 46-50
                a Institute of Pharmacology and Toxicology and b Department of Nephrology, Martin Luther University of Halle-Wittenberg, Halle, Germany
                45124 Nephron 1998;80:46–50
                © 1998 S. Karger AG, Basel

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                Page count
                Tables: 2, References: 23, Pages: 5
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/45124
                Original Paper

                Cardiovascular Medicine, Nephrology

                α-Adrenoceptors, Hemodialysis, β-Adrenoceptors


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