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      Effects of Uremic Plasma on α- and β-Adrenoceptor Subtypes

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          Abstract

          Responsiveness of adrenergic receptors is decreased in patients on maintenance hemodialysis. In this study we investigated whether uremic plasma might affect adrenergic receptors. For this purpose we determined the effects of uremic plasma obtained from 10 patients on hemodialysis treatment (mean age 61 ± 3 years, dialysis frequency 3 × 4 h/week, duration of treatment 3 ± 1 years) before and at the end of the 4-hour dialysis treatment on binding of radioligands to β<sub>1</sub>- and β<sub>2</sub>- as well as α<sub>1</sub>- and α<sub>2</sub>-adrenoceptors. Plasma from 6 healthy volunteers served as control; the plasmas were studied in three dilutions: undiluted, 1:1 (v/v) and 1:4 (v/v) with saline diluted. Plasma from healthy control did not significantly affect the number of β<sub>1</sub>- and β<sub>2</sub>- or α<sub>1</sub>- and α<sub>2</sub>-adrenoceptors. On the other hand, uremic plasma significantly decreased the number of β<sub>1</sub>- and β<sub>2</sub>-adrenoceptors; this inhibitory effect was also observed when plasma obtained at the end of the 4-hour dialysis treatment was investigated. On the other hand, uremic plasma did not significantly decrease the number of α<sub>1</sub>- and α<sub>2</sub>-adrenoceptors. We conclude that in patients on maintenance hemodialysis, the presence of inhibitory substance(s) in uremic plasma could be – at least partly – responsible for the β-adrenoceptor hyporesponsiveness; the mechanism leading ot α-adrenoceptor hyporesponsiveness, however, remains to be elucidated.

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          Most cited references 4

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          Effect of chronic uremia on the cardiovascular alpha 1 receptor.

          Adrenergic dysfunction in uremia has been well described. Several lines of evidence suggest disorders of blood pressure regulation and myocardial response may occur secondary to adrenergic dysfunction; attenuated pressor response to norepinephrine (NE) in uremia; attenuated chronotropic responses during dialysis induced hypotension. Since the adrenergic receptors are the effector component of the adrenergic nervous system, we have employed the partially nephrectomized uremic rat, to examine the effect of chronic uremia (4-6 weeks) on the binding properties of alpha 1 receptors in rat mesenteric artery and myocardial tissue. The results indicate that moderate levels of uremia alter the binding properties of both the alpha 1 vascular and myocardial receptor.
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            Correlation between human myometrial and platelet α2-adrenoceptor density

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              Selective labelling of β1-adrenoceptors in rabbit lung membranes by (−)[3H]bisoprolol

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                Author and article information

                Journal
                NEF
                Nephron
                10.1159/issn.1660-8151
                Nephron
                S. Karger AG
                1660-8151
                2235-3186
                1998
                September 1998
                04 September 1998
                : 80
                : 1
                : 46-50
                Affiliations
                a Institute of Pharmacology and Toxicology and b Department of Nephrology, Martin Luther University of Halle-Wittenberg, Halle, Germany
                Article
                45124 Nephron 1998;80:46–50
                10.1159/000045124
                9730702
                © 1998 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Tables: 2, References: 23, Pages: 5
                Product
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/45124
                Categories
                Original Paper

                Cardiovascular Medicine, Nephrology

                α-Adrenoceptors, Hemodialysis, β-Adrenoceptors

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