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      Inhibition of Basal Insulin Secretion Induces Insulin Resistance in Normal Man: Evidence for a Tonic Effect of Insulin on Carbohydrate Metabolism

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          Abstract

          Insulin resistance has been demonstrated both in insulin deficiency and insulin excess in man and in animals. This study was carried out in normal man to evaluate the role of insulinopenia in the pathogenesis of insulin resistance. Insulin suppression was obtained by 4 h somatostatin (SRIF) infusion. Insulin receptors on circulating monocytes were evaluated before and after SRIF infusion; an insulin tolerance test (ITT) was performed after SRIF, saline or SRIF and replacing basal insulin secretion. Insulin binding to circulating monocytes did not change after 4 h insulinopenia (2.19 ± 0.30 vs. 2.35 ± 0.80%), while insulin sensitivity appeared decreased after SRIF (K<sub>ITT</sub> = 0.97 ± 0.13) as compared with saline (K<sub>ITT</sub> = 3.30 ± 0.42), and this effect was prevented by insulin (K<sub>ITT</sub> = 2.46 ± 0.38). A relationship was detected between K<sub>ITT</sub> and plasma insulin concentration before ITT (r = 0.85, p < 0.01), suggesting that insulin deficiency is the main cause of the phenomenon observed. The present data suggest that basal insulin concentration plays an essential role in the control of insulin sensitivity. If insulin binding on monocytes mimics the behavior of major insulin target tissues, it is possible that the impaired insulin action after 4 h of insulin deficiency is related to a post binding effect.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1989
          1989
          02 December 2008
          : 31
          : 5-6
          : 238-243
          Affiliations
          Istituto di Clinica Medica, Università Cattolica SC, Roma, Italia
          Article
          181124 Horm Res 1989;31:238–243
          10.1159/000181124
          2575575
          b5af93d0-318f-4ec7-a9bd-877b89b7cd0d
          © 1989 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 09 September 1988
          : 19 April 1989
          Page count
          Pages: 6
          Categories
          Original Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Insulin receptors,Somatostatin,Insulin deficiency,Insulin resistance

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