6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      A meta-analysis of clinical electro-oculography values

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Related collections

          Most cited references51

          • Record: found
          • Abstract: found
          • Article: found

          ISCEV Standard for clinical electro-oculography (2017 update)

          The clinical electro-oculogram (EOG) is an electrophysiological test of the outer retina and retinal pigment epithelium (RPE) in which changes in the electrical potential across the RPE are recorded during successive periods of dark and light adaptation. This document presents the 2017 EOG Standard from the International Society for Clinical Electrophysiology of Vision (ISCEV: www.iscev.org). This standard has been reorganized and updated to include an explanation of the mechanism of the EOG, but without substantive changes to the testing protocol from the previous version published in 2011. It describes methods for recording the EOG in clinical applications and gives detailed guidance on technical requirements, practical issues and reporting of results with the main clinical measure (the Arden ratio) now termed the light peak:dark trough ratio. The standard is intended to promote consistent quality of testing and reporting within and between clinical centers.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Autosomal recessive bestrophinopathy: differential diagnosis and treatment options.

            To describe the clinical and genetic characteristics of patients with autosomal recessive bestrophinopathy (ARB).
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Bestrophins and retinopathies.

              Best vitelliform macular dystrophy (BVMD, also called Best's disease) is a dominantly inherited, juvenile-onset form of macular degeneration, which is characterized by abnormal accumulation of yellow pigment in the outer retina and a depressed electro-oculogram light peak (LP). Over 100 disease-causing mutations in human bestrophin-1 (hBest1) are closely linked to BVMD and several other retinopathies. However, the physiological role of hBest1 and the mechanisms of retinal pathology remain obscure partly because hBest1 has been described as a protein with multiple functions including a Ca2+-activated Cl- channel, a Ca2+ channel regulator, a volume-regulated Cl- channel, and a HCO3- channel. This review focuses on how dysfunction of hBest1 is related to the accumulation of yellow pigment and a decreased LP. The dysfunction of hBest1 as a HCO3- channel or a volume-regulated Cl- channel may be associated with defective regulation of the subretinal fluid or phagocytosis of photoreceptor outer segments by retinal pigment epithelium cells, which may lead to fluid and pigment accumulation.
                Bookmark

                Author and article information

                Journal
                Documenta Ophthalmologica
                Doc Ophthalmol
                Springer Nature America, Inc
                0012-4486
                1573-2622
                December 2017
                October 10 2017
                December 2017
                : 135
                : 3
                : 219-232
                Article
                10.1007/s10633-017-9616-8
                b5cdf490-b807-4083-92a1-8c1f00d55c89
                © 2017

                http://www.springer.com/tdm

                History

                Comments

                Comment on this article