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      Genetic cause of hyperglycaemia and response to treatment in diabetes.

      Lancet (London, England)
      Elsevier BV

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          Abstract

          Type 2 diabetes shows evidence of underlying heterogeneity. No studies have assessed whether different causes for diabetes change the response to oral hypoglycaemic therapy. In a few cases, patients with diabetes caused by mutations in the hepatocyte nuclear factor 1alpha (HNF-1alpha) gene have been described as sensitive to the hypoglycaemic effects of sulphonylureas. We aimed to see whether the glycaemic response to the sulphonylurea gliclazide and the biguanide metformin differed in HNF-1alpha diabetes and type 2 diabetes, and to investigate the mechanism for differences in sulphonylurea sensitivity.

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          Author and article information

          Journal
          14575972
          10.1016/S0140-6736(03)14571-0

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