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Abstract
Raynaud, digital ulcers and calcinosis are frequent manifestations of patients with
systemic sclerosis. Digital ulcers are seen in more than half of the patients with
scleroderma. Hospitalizations, ischemic complications and impairment of hand function
are frequently observed in patients with digital ulcers, especially if treatment is
delayed. Rapid and intensive treatment escalation in patients with scleroderma and
refractory Raynaud's phenomenon is one of the most effective preventive action available
in order to avoid the development of digital ulcers and tissue loss.