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      Circadian Rhythms

      Hormone Research in Paediatrics

      S. Karger AG

      Circadian rhythms, Circadian clock, Suprachiasmatic nucleus, Pineal gland, Melatonin, Clock genes

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          1997 marks the 25th anniversary of the discovery of the master circadian pacemaker in mammals in the hypothalamic suprachiasmatic nucleus. Remarkable progress has been made over the last 25 years in elucidating the physiological mechanisms involved in the entrainment, generation and expression of circadian rhythms at the cellular and systems levels. The recent discovery and cloning of the first mammalian clock gene is expected to lead to rapid advances in the understanding of the genetic and molecular mechanisms underlying circadian rhythmicity in mammals. Indeed, the impressive and extensive database on circadian rhythms in mammals obtained over the past 25 years provides a foundation for making rapid progress in utilizing future genetic and molecular findings for discovering the fundamental mechanisms controlling 24-hour temporal organization.

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          Most cited references 1

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          Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat.


            Author and article information

            Horm Res Paediatr
            Hormone Research in Paediatrics
            S. Karger AG
            March 1998
            16 March 1998
            : 49
            : 3-4
            : 109-113
            Center for Circadian Biology and Medicine, Northwestern University, Evanston, Ill., USA
            23155 Horm Res 1998;49:109–113
            © 1998 S. Karger AG, Basel

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            Page count
            Figures: 2, References: 23, Pages: 5


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