For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
149
views
102
references
 Top references
cited by
201
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    4
    shares
      122
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      mRNP granules : Assembly, function, and connections with disease

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Messenger ribonucleoprotein (mRNP) granules are dynamic, self-assembling structures that harbor non-translating mRNAs bound by various proteins that regulate mRNA translation, localization, and turnover. Their importance in gene expression regulation is far reaching, ranging from precise spatial-temporal control of mRNAs that drive developmental programs in oocytes and embryos, to similarly exquisite control of mRNAs in neurons that underpin synaptic plasticity, and thus, memory formation. Analysis of mRNP granules in their various contexts has revealed common themes of assembly, disassembly, and modes of mRNA regulation, yet new studies continue to reveal unexpected and important findings, such as links between aberrant mRNP granule assembly and neurodegenerative disease. Continued study of these enigmatic structures thus promises fascinating new insights into cellular function, and may also suggest novel therapeutic strategies in various disease states.

          Related collections

          Most cited references102

          • Record: found
          • Abstract: found
          • Article: not found

          Stress granules: the Tao of RNA triage.

          Paul. Anderson, Nancy Kedersha (2008)
          Cytoplasmic RNA structures such as stress granules (SGs) and processing bodies (PBs) are functional byproducts of mRNA metabolism, sharing substrate mRNA, dynamic properties and many proteins, but also housing separate components and performing independent functions. Each can exist independently, but when coordinately induced they are often tethered together in a cytosolic dance. Although both self-assemble in response to stress-induced perturbations in translation, several recent reports reveal novel proteins and RNAs that are components of these structures but also perform other cellular functions. Proteins that mediate splicing, transcription, adhesion, signaling and development are all integrated with SG and PB assembly. Thus, these ephemeral bodies represent more than just the dynamic sorting of mRNA between translation and decay.
          Article 0 comments Cited 397 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish.

            Saskia Houwing, Leonie M. Kamminga, Eugene Berezikov … (2007)
            Piwi proteins specify an animal-specific subclass of the Argonaute family that, in vertebrates, is specifically expressed in germ cells. We demonstrate that zebrafish Piwi (Ziwi) is expressed in both the male and the female gonad and is a component of a germline-specifying structure called nuage. Loss of Ziwi function results in a progressive loss of germ cells due to apoptosis during larval development. In animals that have reduced Ziwi function, germ cells are maintained but display abnormal levels of apoptosis in adults. In mammals, Piwi proteins associate with approximately 29-nucleotide-long, testis-specific RNA molecules called piRNAs. Here we show that zebrafish piRNAs are present in both ovary and testis. Many of these are derived from transposons, implicating a role for piRNAs in the silencing of repetitive elements in vertebrates. Furthermore, we show that piRNAs are Dicer independent and that their 3' end likely carries a 2'O-Methyl modification.
            Article 0 comments Cited 346 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function.

              Eric Lécuyer, Hideki Yoshida, Neela Parthasarathy … (2007)
              Although subcellular mRNA trafficking has been demonstrated as a mechanism to control protein distribution, it is generally believed that most protein localization occurs subsequent to translation. To address this point, we developed and employed a high-resolution fluorescent in situ hybridization procedure to comprehensively evaluate mRNA localization dynamics during early Drosophila embryogenesis. Surprisingly, of the 3370 genes analyzed, 71% of those expressed encode subcellularly localized mRNAs. Dozens of new and striking localization patterns were observed, implying an equivalent variety of localization mechanisms. Tight correlations between mRNA distribution and subsequent protein localization and function, indicate major roles for mRNA localization in nucleating localized cellular machineries. A searchable web resource documenting mRNA expression and localization dynamics has been established and will serve as an invaluable tool for dissecting localization mechanisms and for predicting gene functions and interactions.
              Article 0 comments Cited 340 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): RNA Biol
                Journal ID (iso-abbrev): RNA Biol
                Journal ID (pmc): KRNB
                Title: RNA Biology
                Publisher: Taylor & Francis
                ISSN (Print): 1547-6286
                ISSN (Electronic): 1555-8584
                Publication date Collection: August 2014
                Publication date (Electronic): 22 December 2014
                Volume: 11
                Issue: 8
                Pages: 1019-1030
                Affiliations
                Department of Molecular and Cellular Biology; University of Arizona ; Tucson, AZ USA
                Author notes
                [* ]Correspondence to: J Ross Buchan; Email: rbuchan@ 123456email.arizona.edu
                Article
                Publisher ID: 972208
                DOI: 10.4161/15476286.2014.972208
                PMC ID: 4615263
                PubMed ID: 25531407
                SO-VID: b5eb2423-68f3-4276-b08b-61f3e87133e1
                Copyright © © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC© J Ross Buchan
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

                History
                Date received : 15 April 2014
                Date accepted : 28 April 2014
                Page count
                Figures: 2, Tables: 0, References: 149, Pages: 12
                Categories
                Subject: Review

                ScienceOpen disciplines: Molecular biology
                Keywords: stress granules,p-bodies,neuronal transport granules,germ granules,mrna,translation,repression,decay,neurodegenerative disease
                Data availability:
                ScienceOpen disciplines: Molecular biology
                Keywords: stress granules, p-bodies, neuronal transport granules, germ granules, mrna, translation, repression, decay, neurodegenerative disease

                Comments

                Comment on this article

                scite_

                Similar content122

                See all similar

                Cited by199

                See all cited by

                Most referenced authors1,704

                See all reference authors