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      The Identification of Anthranilic Acid in Proteolytic Digests of Cataractous Lens Proteins

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          Abstract

          The yellow protein fractions and brown insoluble proteins from nuclear cataractous lenses and the total proteins from normal lenses were digested with pronase, prolidase and leucine aminopeptidase and the digests were fractioned on Sephadex G-25. Anthranilic acid was identified as a component of the cataractous protein digests but was absent from the normal protein digest. It is suggested that a possible source of the anthranilic acid is tryptophan which was oxidized during nuclear cataract formation.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1977
          1977
          03 December 2009
          : 9
          : 4
          : 263-268
          Affiliations
          Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Vic.
          Article
          264894 Ophthalmic Res 1977;9:263–268
          10.1159/000264894
          b5ec2830-984f-4012-9f7b-6463ee56a3a6
          © 1977 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 20 July 1977
          : 15 September 1977
          Page count
          Pages: 6
          Categories
          Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Fluorescence,Proteolysis,Anthranilic acid,Yellow protein fraction,Nuclear cataract,Human lens proteins

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