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      Association of chemokine receptor 5 (CCR5) delta32 mutation with Behçet's disease is dependent on gender in Iranian patients.

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          Abstract

          Behçet's disease (BD) is a recurrent multi-system inflammatory disorder caused by the combinations of multiple genetic and environmental factors. CCR5 is a Th1-dominant chemokine receptor whose levels are increased in patients with active BD. It is believed that a 32 bp deletion in the CCR5 gene reduces the expression of this receptor on the cell surface. The aim of the present study was to investigate the association of CCR5 delta32 allele with BD in Iranian patients.

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          Author and article information

          Journal
          Clin. Exp. Rheumatol.
          Clinical and experimental rheumatology
          0392-856X
          0392-856X
          : 24
          : 5 Suppl 42
          Affiliations
          [1 ] Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Hafez Hospital, Shiraz, Iran.
          Article
          1892
          17067435

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