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      Total synthesis of LL-Z1640-2 utilizing a late-stage intramolecular Nozaki-Hiyama-Kishi reaction.

      1 , , ,
      Tetrahedron letters
      Elsevier BV

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          Abstract

          A total synthesis of LL-Z1640-2 (2), a potent and selective kinase inhibitor, has been completed. The key step of the convergent synthesis utilized a late-stage intramolecular Nozaki-Hiyama-Kishi (NHK) reaction to close the macrocycle at the C6'-C7' bond.

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          Author and article information

          Journal
          Tetrahedron Lett
          Tetrahedron letters
          Elsevier BV
          0040-4039
          0040-4039
          Dec 29 2010
          : 51
          : 52
          Affiliations
          [1 ] NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA.
          Article
          NIHMS249298
          10.1016/j.tetlet.2010.10.092
          3079232
          21516235
          b6136d49-ac85-4333-a255-0f9b336042b6
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