Blog
About

0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Blood Leukocyte Contribution to Serum Ferritin Levels in Patients on Chronic Hemodialysis

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Serum ferritin level has been shown by many investigators to be a good indicator of bone marrow iron stores in normal subjects. Although this correlation may hold in some pathological situations, it is lost in others. In leukemia a dissociation has been observed between serum ferritin levels and bone marrow iron stores. Leukemic cells were demonstrated to contain high levels of ferritin and to secrete it in the serum, causing this dissociation. In this study we investigated the possibility of having an analogous situation in patients on chronic hemodialysis. The latter patients have normal or high ferritin levels irrespective of bone marrow iron stores. Our results show that blood neutrophils and lymphocytes do not contribute to the high serum ferritin levels in these patients. Ferritin level in blood monocytes, however, was found to correlate with the serum ferritin levels and bone marrow iron stores in dialysis patients. Hence we concluded that sources other than blood leukocytes must be contributing to the high serum ferritin level in these patients. On the other hand, to unravel the role played in these changes by the monocytic cell population requires dynamic studies.

          Related collections

          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1991
          1991
          11 December 2008
          : 57
          : 2
          : 144-148
          Affiliations
          Departments of aHuman Morphology and bInternal Medicine, Faculty of Medicine, The American University of Beirut, Lebanon
          Article
          186241 Nephron 1991;57:144–148
          10.1159/000186241
          2020340
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

          Comments

          Comment on this article