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      Glycosides in Medicine: “The Role of Glycosidic Residue in Biological Activity”

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      Current Medicinal Chemistry
      Bentham Science Publishers Ltd.

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          Abstract

          Numbers of biologically active compounds are glycosides. Sometimes, the glycosidic residue is crucial for their activity, in other cases glycosylation only improves pharmacokinetic parameters. Recent developments in molecular glycobiology brought better understanding to the aglycone vs. glycoside activities, and made possible to develop new, more active or more effective glycodrugs based on these findings - very illustrative recent example is the story of vancomycin. This paper deals with an array of glycosidic compounds currently used in medicine but also with biological activity of some glycosidic metabolites of the known drugs. It involves glycosides of vitamins, polyphenolic glycosides (flavonoids), alkaloid glycosides, glycosides in the group of antibiotics, glycopeptides, cardiac glycosides, steroid and terpenoid glycosides etc. The physiological role of the glycosyl and structure-activity relations (SAR) in the glycosidic moiety (-ies) are discussed.

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          Author and article information

          Journal
          Current Medicinal Chemistry
          CMC
          Bentham Science Publishers Ltd.
          09298673
          September 01 2001
          September 01 2001
          : 8
          : 11
          : 1303-1328
          Article
          10.2174/0929867013372193
          11562268
          b62f7a85-3d8a-43d3-9a51-d317e3f05026
          © 2001
          History

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