Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype.

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Abstract

Motor slowing appears in preclinical Alzheimer disease (AD), progresses with AD progression, and is associated with AD pathologic findings at autopsy. Whether amyloid-β (Aβ) is associated with gait speed in elderly individuals without dementia and whether cognition and apolipoprotein E ε4 (APOE ε4) influence this association remain unknown.

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Journal

Journal ID (iso-abbrev): JAMA Neurol

Title: JAMA neurology

Publisher: American Medical Association (AMA)

ISSN (Electronic): 2168-6157

ISSN (Print): 2168-6149

Publication date (Electronic): Jan 01 2017

Volume: 74

Issue: 1

Affiliations

[1 ] Division of Geriatric Medicine and Gerontology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania2Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania.

[2 ] Division of Geriatric Medicine and Gerontology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania3Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania.

[3 ] Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania4Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania.

[4 ] Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania5Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.

[5 ] Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania6currently with Department of Radiology, Harvard University, Boston, Massachusetts.

[6 ] Section on Geriatrics and Gerontology, Department of Internal Medicine, Wake Forest University, Winston-Salem, North Carolina.

[7 ] Department of Neurology, University of Florida, Gainesville, Florida.

[8 ] Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania9Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.

Article

Publisher Item ID: 2580475

DOI: 10.1001/jamaneurol.2016.3474

PubMed ID: 27842173

SO-VID: b64ef634-df39-4c8a-9165-bf89eae32963

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