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      Cytokines Enhance the Production of a Chemotactic Factor for Polymorphonuclear Leukocytes by Rat Renal Glomerular Epithelioid Cells

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          Abstract

          Human recombinant interleukin-1β (IL-1) and tumor necrosis factor-α (TNF) dose-dependently enhanced the production of PMN chemotactic factor, which was trypsin-sensitive and heat-stable, by the epithelioid cells of rat renal glomeruli. Dexamethasone dose-dependently suppressed the chemoattractant production. Molecular weight and isoelectric point of this factor were 10 kDa and over 10, respectively. These results suggest that PMN migration to glomeruli occurs without participation of complement system when TNF or/and IL-1 are produced by activated cells in glomeruli.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1990
          1990
          10 December 2008
          : 54
          : 2
          : 169-175
          Affiliations
          Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
          Article
          185839 Nephron 1990;54:169–175
          10.1159/000185839
          2179756
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Original Paper

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