Transfer of Steroidal Hormones from Blood to the Cerebrospinal Fluid in the Rhesus Monkey

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Abstract

Rhesus monkeys were injected intravenously with tritium-labeled testosterone (T), progesterone (P), 17 α-hydroxyprogesterone (17 OHP), norethynodrel (N) and mestranol (M) to determine whether these steroids can enter the cerebrospinal fluid (CSF). These studies showed that all these steroids can enter the CSF. The concentrations of T and P in the plasma were consider-ably more than those found in the CSF, whereas the levels of 17 OHP, M and N were considerably more in the CSF than in the plasma. The possible significance of this difference is discussed.

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Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1974

Publication date (Print): 1974

Publication date (Electronic): 20 March 2008

Volume: 14

Issue: 2

Pages: 114-120

Affiliations

Neuroendocrine Research Laboratory, Department of Anatomy, All-India Institute of Medical Sciences, New Delhi

Article

Publisher ID: 122251 Other ID: Neuroendocrinology 1974;14:114–120

DOI: 10.1159/000122251

PubMed ID: 4206963

SO-VID: b65abae2-f6a8-4a43-8c4f-181dcce690e6

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 06 July 1973

Date accepted : 09 September 1973

Page count

Pages: 7

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