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      Recent advances in magnetic targeting based on high magnetic field and magnetic particles

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          In the past few decades, the multifunctional magnetic drug carrier based on the magnetic nanoparticles and high magnetic field has been intensively researched. The magnetic drug carrier can be targeted to the tumour area not only by the chemical protocol but also by the physical one (external field). In this review, the authors first briefly discuss the fabrication process of magnetic drug carriers, which includes the synthesis of magnetic nanoparticles, fabrication of magnetic drug carriers and conjugation of anti-tumour agents. Then different targeted protocols have been summarised, including passive targeting, biochemical active targeting and biophysical active targeting namely magnetic targeting (MT). Multiple MT results both in vitro and in vivo are introduced, in which two unconventional cases are emphasised and described. The first MT clinical research with 14 peoples was performed in the last century. A 0.5–0.8 T permanent magnet was attached to the tumour area when magnetic particles conjugated with epirubicin were injected. The side effect of epirubicin had been decreased, and the four patients showed the decreasing of a tumour which proved the feasibility of MT. Different from other targeting protocols, MT needs an extra external magnetic field. So various types of MT instruments have been shown in the final part of this review, including a single strong magnetic field, homemade electronic solenoid coil assay and commercial magnetic resonance imaging.

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          Most cited references 79

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                Author and article information

                High Voltage
                High Volt.
                The Institution of Engineering and Technology
                11 September 2017
                24 October 2017
                December 2017
                : 2
                : 4
                : 220-232
                [1 ] Institute of Electrical Engineering, Chinese Academy Sciences , Beijing 100190, People's Republic of China
                [2 ] Xiyuan Hospital of China Academy of Chinese Medical Sciences , Beijing 100019, People's Republic of China
                HVE.2017.0082 HVE.2017.0082.R1

                This is an open access article published by the IET and CEPRI under the Creative Commons Attribution-NonCommercial-NoDerivs License ( http://creativecommons.org/licenses/by-nc-nd/3.0/)

                Page count
                Pages: 0
                Funded by: National Natural Science Foundation of China
                Award ID: 11545004
                Award ID: 51477167
                Review Article


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