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      Biological and magnetic contrast evaluation of shape-selective Mn-Fe nanowires.

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          Abstract

          One-dimensional composite Mn-Fe oxide nanostructures of different sizes (nanoneedles, nanorods, and nanowires) were prepared by a linker-induced organization of manganese-doped iron oxide nanoparticles. The nanostructures were obtained by the treatment of MnFe(2)O(4) nanoparticles in the presence of cystamine. The average lengths of nanoneedle, nanorod, and nanowire are approximately 400, 800, and 1000 nm, respectively. High-resolution transmission electron microscopy (HR-TEM), energy-dispersive X-ray (EDX) spectroscopy, and inductively coupled plasma-optical emission spectroscopy (ICP-OES) were employed to characterize the morphologies and the elemental contents of the nanostructures. As an example of their potential applications, these nanostructures were explored as the cell-labeling agents for magnetic resonance imaging (MRI). The magnetic contrast properties of the nanostructures were characterized by a 1.5 T (Tesla) whole body MR system. 10 microg/mL of the nanostructures caused substantial negative contrast. After in vitro incubation, the nanostructures could be effectively incorporated into the cells of a monocyte/macrophage cell line (RAW264.7). These cells' viability and proliferation potential were not affected when the labeling concentration was less than 50 microg/mL.

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          Author and article information

          Journal
          IEEE Trans Nanobioscience
          IEEE transactions on nanobioscience
          Institute of Electrical and Electronics Engineers (IEEE)
          1558-2639
          1536-1241
          Jun 2009
          : 8
          : 2
          Affiliations
          [1 ] Center of Novel Functional Molecules, Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong. cfleung@cuhk.edu.hk
          Article
          10.1109/TNB.2009.2021521
          19435685
          b6674ed9-bc2d-4382-80f6-ee25365dbb5f
          History

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