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      Correlation between Retina Blood Flow Velocity Assessed by Retinal Function Imager and Retina Thickness Estimated by Scanning Laser Ophthalmoscopy/Optical Coherence Tomography

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          Purpose: The purpose of this study was to evaluate the correlation between the retinal blood flow (RBF) assessed by the retinal functional imager (RFI) and central macular thickness/volume assessed by a spectral scanning laser ophthalmoscopy/optical coherence tomography (SLO-OCT) system. Methods: Seventeen eyes of 14 consecutive patients with various ocular diseases were examined. Retinal blood circulation characteristics were measured using the RFI. Retinal thickness/volume parameters were obtained by SLO-OCT. Analysis of correlation between RBF velocity and SLO-OCT findings was performed. Results: The analysis of the correlation between RBF and central retinal thickness/volume (5 × 5 mm grid pattern) showed a strong correlation between the average venous RBF velocity and central retinal volume. A linear relationship between the retinal blood velocity in veins and center, middle ring, outer ring and total central squares of macular volume [correlation coefficient 0.86 (p = 0.00001); 0.89 (p = 0.000001); 0.82 (p = 0.0004); 0.85 (p = 0.00001), respectively] has been observed. Arterial blood flow velocity did not correlate with thickness and with central retinal volume. Conclusions: Venous RBF, analyzed by the RFI, significantly correlated with the volume of the central retina, measured by SLO-OCT. Venous blood velocity increased linearly with the increase in the central retinal volume. In this small study, assessment using the RFI provides useful information and may contribute to the further understanding of hemodynamics in the retina blood vessels. The RFI shows promise of being able to analyze retinal hemodynamics noninvasively and may contribute to the further understanding of the relationship between retinal thickening and function.

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          Most cited references 12

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          Alteration of choroidal circulation in the foveal region in patients with type 2 diabetes.

          To investigate changes in choroidal blood flow (CBF) in the foveal region in patients with type 2 diabetes. Laser Doppler flowmetry was used to determine the CBF in the foveal region in 70 patients with type 2 diabetes and 36 age and sex matched healthy subjects (control group). The patients were classified into three groups: 33 patients (33 eyes) with no diabetic retinopathy (NDR), 20 patients (20 eyes) with non-proliferative diabetic retinopathy and no macular oedema (NPDR/MO-), and 17 patients (17 eyes) with NPDR and MO (NPDR/MO+). Optical coherence tomography was also used to measure the foveal thickness. The group averaged CBF values were 13.5 (4.9), 9.4 (2.5), 10.8 (4.8), and 5.6 (2.0) (arbitrary units) in the control, NDR, NPDR/MO-, and NPDR/MO+ groups, respectively. The group averaged CBF values in the NDR group decreased (30.2%; p<0.01) compared with the control group. The average CBF value in the NPDR/MO+ group was also significantly lower (48.2%; p<0.01) compared with that in the NPDR/MO- group. The CBF in the foveal region significantly decreases in patients with diabetes, especially those with macular oedema.
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            Blue field entoptic phenomenon and blood velocity in the retinal capillaries.

             B Petrig,  C Riva (1980)
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              Scanning electron-microscopic study of corrosion casts on retinal and choroidal angioarchitecture in man and animals

               Hui Zhang (1994)

                Author and article information

                S. Karger AG
                May 2009
                12 January 2009
                : 223
                : 3
                : 155-161
                aRetina Center, Department of Ophthalmology, New York Eye and Ear Infirmary, New York, N.Y., USA; bDepartment of Ophthalmology, Kaplan Medical Center, Rehovot, Israel
                189819 Ophthalmologica 2009;223:155–161
                © 2009 S. Karger AG, Basel

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                Page count
                Figures: 3, References: 24, Pages: 7
                Original Paper


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