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      Evidence for involvement of spinal RANTES in the antinociceptive effects of triptolide, a diterpene triepoxide, in a rat model of bone cancer pain.

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          Abstract

          It has been shown that triptolide has beneficial effects in the treatment of neuropathic pain, but its effects on bone cancer pain (BCP) remain unclear. In this study, we aimed to explore the potential role of spinal regulated activation of normal T cell expressed and secreted (RANTES) in the antinociceptive effects of triptolide on BCP. A BCP model was induced by injecting Walker 256 mammary gland carcinoma cells into the intramedullary space of rat tibia. Intrathecal administration of triptolide (0.5, 1, 2 μg) could dose-dependently alleviate mechanical hyperalgesia and spontaneous pain. In addition, there were also concomitant decreases in RANTES mRNA and protein expression levels in spinal dorsal horn. These results suggest that the antinociceptive effects of triptolide are related with inhibition of spinal RANTES expression in BCP rats. The findings of this study may provide a promising drug for the treatment of BCP.

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          Author and article information

          Journal
          Basic Clin. Pharmacol. Toxicol.
          Basic & clinical pharmacology & toxicology
          1742-7843
          1742-7835
          Dec 2014
          : 115
          : 6
          Affiliations
          [1 ] Department of Anesthesiology, the Affiliated People's Hospital of Jiangsu University, Zhenjiang Jiangsu, China.
          Article
          10.1111/bcpt.12265
          24810483
          b66cf909-63fa-4ed2-a004-a28758acd076
          © 2014 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).
          History

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