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      Phentolamine mesylate for accelerating recovery from lip and tongue anesthesia.

      1 ,
      Dental clinics of North America
      Elsevier BV

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          Abstract

          Phentolamine mesylate, at dosages from 0.4 to 0.8 mg in adults and adolescents and at dosages from 0.2 to 0.4 mg in children aged 4 to 11 years, has been proven to be safe and effective for the reversal of soft tissue anesthesia (lip and tongue numbness) and the associated functional deficits resulting from a local dental anesthetic injection containing a vasoconstrictor. Its ability to block a-adrenergic receptors on blood vessels induces vasodilation and enhances the redistribution of the local anesthetic away from the injection site. The low dosages administered for dental local anesthetic reversal in all likelihood accounts for the lack of significant cardiovascular effects that are associated with the medical use of the drug for hypertensive conditions associated with catecholamine excess.

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          Author and article information

          Journal
          Dent. Clin. North Am.
          Dental clinics of North America
          Elsevier BV
          1558-0512
          0011-8532
          Oct 2010
          : 54
          : 4
          Affiliations
          [1 ] Department of Oral Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104-6030, USA. evhersh@pobox.upenn.edu
          Article
          S0011-8532(10)00062-5
          10.1016/j.cden.2010.06.004
          20831927
          b678d54f-0bd3-4193-bc0e-1613cbf19866
          History

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