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      Colistin Resistance Gene mcr-8 in a High-Risk Sequence Type 15 Klebsiella pneumoniae Isolate from Kenya

      brief-report
      Author(s): a , a ,
      Editor(s):
      Publication date (Electronic):
      Journal: Microbiology Resource Announcements
      Publisher: American Society for Microbiology

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          Abstract

          The emergence and rise of mobile colistin resistance genes are of great global concern due to the ease of transfer of resistance to other bacteria. This report describes the genome of a colistin- and multidrug-resistant Klebsiella pneumoniae isolate bearing mcr-8, obtained from a hospitalized patient in Kenya.

          ABSTRACT

          The emergence and rise of mobile colistin resistance genes are of great global concern due to the ease of transfer of resistance to other bacteria. This report describes the genome of a colistin- and multidrug-resistant Klebsiella pneumoniae isolate bearing mcr-8, obtained from a hospitalized patient in Kenya.

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          Genetic Features of MCR-1-Producing Colistin-Resistant Escherichia coli Isolates in South Africa.

          Laurent Poirel, Nicolas Kieffer, Adrian J Brink … (2016)
          A series of colistin-resistant Escherichia coli clinical isolates was recovered from hospitalized and community patients in South Africa. Seven clonally unrelated isolates harbored the mcr-1 gene located on different plasmid backbones. Two distinct plasmids were fully sequenced, and identical 2,600-bp-long DNA sequences defining a mcr-1 cassette were identified. Promoter sequences responsible for the expression of mcr-1, deduced from the precise identification of the +1 transcription start site for mcr-1, were characterized.
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            An overview of colistin resistance, mobilized colistin resistance genes dissemination, global responses, and the alternatives to colistin: A review

            Mohammad H. Gharaibeh, Shoroq Shatnawi (2019)
            Colistin, also known as polymyxin E, is an antimicrobial agent that is effective against a variety of Gram-negative bacilli, especially the Enterobacteriaceae family. Recently, the wide dissemination of colistin-resistance has brought strong attention to the scientific society because of its importance as the last resort for the treatment of carbapenem-resistant Enterobacteriaceae infections and its possible horizontal transmission. The mobilized colistin resistance (mcr) gene was identified as the gene responsible for unique colistin resistance. Indeed, despite many studies that have revealed a pan variation in the existence of this gene, not only for the mcr genes main group but also for its many subgroups, the problem is growing and worsening day after day. In this regard, this review paper is set to review the updated data that has been published up to the end of 2019 third quarter, especially when related to colistin resistance by the mcr genes. It will include the present status of colistin resistance worldwide, the mcr gene dissemination in different sectors, the discovery of the mcr variants, and the global plan to deal with the threat of antimicrobial resistance. In line with global awareness, and to stop antibiotic misuse and overuse, especially in agricultural animals, the study will further discuss in detail the latest alternatives to colistin use in animals, which may contribute to the elimination of inappropriate antibiotic use and to the help in preventing infections. This review will advance our understanding of colistin resistance, while supporting the efforts toward better stewardship, for the proper usage of antimicrobial drugs in humans, animals, and in the environment.
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              Impact of food animal trade on the spread of mcr-1-mediated colistin resistance, Tunisia, July 2015.

              Raoudha Grami, Wejdene Mansour, Wahib Mehri … (2016)
              We report a high prevalence of MCR-1 and CTX-M-1-producing Escherichia coli in three Tunisian chicken farms. Chickens were imported from France or derived from French imported chicks. The same IncHI2-type plasmid reported to carry those genes in cattle in France and in a food sample in Portugal was found in Tunisian chickens of French origin. This suggests a significant impact of food animal trade on the spread of mcr-1-mediated colistin resistance in Europe.
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                Author and article information

                Contributors
                John J. Dennehy: Role: Editor
                Journal
                Journal ID (nlm-ta): Microbiol Resour Announc
                Journal ID (iso-abbrev): Microbiol Resour Announc
                Journal ID (hwp): ga
                Journal ID (pmc): mra
                Journal ID (publisher-id): MRA
                Title: Microbiology Resource Announcements
                Publisher: American Society for Microbiology (1752 N St., N.W., Washington, DC )
                ISSN (Electronic): 2576-098X
                Publication date (Electronic): 24 September 2020
                Publication date Collection: September 2020
                Volume: 9
                Issue: 39
                Electronic Location Identifier: e00783-20
                Affiliations
                [a ]U.S. Army Medical Research Directorate-Africa, Nairobi, Kenya
                Queens College
                Author notes
                Address correspondence to Lillian Musila, lillian.musila@ 123456usamru-k.org .

                Citation Kyany’a C, Musila L. 2020. Colistin resistance gene mcr-8 in a high-risk sequence type 15 Klebsiella pneumoniae isolate from Kenya. Microbiol Resour Announc 9:e00783-20. https://doi.org/10.1128/MRA.00783-20.

                Author information
                https://orcid.org/0000-0001-6293-5264
                https://orcid.org/0000-0003-1418-6523
                Article
                Publisher ID: MRA00783-20
                DOI: 10.1128/MRA.00783-20
                PMC ID: 7516148
                PubMed ID: 32972937
                SO-VID: b67e697e-dbff-4111-a163-a6c416028172
                Copyright © Copyright © 2020 Kyany’a and Musila.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

                History
                Date received : 7 July 2020
                Date accepted : 23 August 2020
                Page count
                Figures: 0, Tables: 1, Equations: 0, References: 17, Pages: 3, Words: 1832
                Funding
                Funded by: DOD | MHS | Armed Forces Health Surveillance Branch (AFHSB), https://doi.org/10.13039/100014035;
                Award ID: ProMIS ID 20160270153 FY17
                Award Recipient :
                Categories
                Subject: Genome Sequences
                Custom metadata
                cover-date September 2020

                Data availability:

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