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Inside Job: Viruses Transfer cGAMP between Cells
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Abstract
The DNA sensor, cyclic GMP-AMP synthase (cGAS), is essential for the detection of
viral infection. In a recent issue of Science, two studies, Bridgeman et al. (2015)
and Gentili et al. (2015), report a novel mechanism for propagating an antiviral signal
between cells, based on the transfer of the cGAS enzymatic product, cyclic GMP-AMP
(cGAMP), in viral particles.