Typhoid is an important public health challenge for India, especially with the spread of antimicrobial resistance. The decision about whether to introduce a public vaccination programme needs to be based on an understanding of disease burden and the age-groups and geographic areas at risk.
We searched Medline and Web of Science databases for studies reporting the incidence or prevalence of typhoid and paratyphoid fever confirmed by culture and/or serology, conducted in India and published between 1950 and 2015. We used binomial and Poisson mixed-effects meta-regression models to estimate prevalence and incidence from hospital and community studies, and to identify risk-factors.
We identified 791 titles and abstracts, and included 37 studies of typhoid and 18 studies of paratyphoid in the systematic review and meta-analysis. The estimated prevalence of laboratory-confirmed typhoid and paratyphoid among individuals with fever across all hospital studies was 9.7% (95% CI: 5.7–16.0%) and 0.9% (0.5–1.7%) respectively. There was significant heterogeneity among studies (p-values<0.001). Typhoid was more likely to be detected among clinically suspected cases or during outbreaks and showed a significant decline in prevalence over time (odds ratio for each yearly increase in study date was 0.96 (0.92–0.99) in the multivariate meta-regression model). Paratyphoid did not show any trend over time and there was no clear association with risk-factors. Incidence of typhoid and paratyphoid was reported in 3 and 2 community cohort studies respectively (in Kolkata and Delhi, or Kolkata alone). Pooled estimates of incidence were 377 (178–801) and 105 (74–148) per 100,000 person years respectively, with significant heterogeneity between locations for typhoid (p<0.001). Children 2–4 years old had the highest incidence.
Typhoid fever is an important cause of avoidable mortality in regions without adequate access to safe water and sanitation. Highly immunogenic typhoid conjugate vaccines are now licensed and under consideration as a public health intervention in India. The decision about whether and how to introduce a public vaccination programme needs to be based on an understanding of disease burden, and the age-groups and geographic areas at risk. We performed a systematic review and meta-analysis of published studies reporting typhoid and paratyphoid incidence and prevalence in India between 1950 and 2015. The estimated prevalence of laboratory-confirmed typhoid and paratyphoid among individuals with fever across all hospital studies was 9.7% (95% CI: 5.7–16.0%) and 0.9% (0.5–1.7%) respectively, with a significant decline in prevalence of the former over time. We found only three population-based studies that reported incidence. Pooled estimates were 377 (178–801) and 105 (74–148) per 100,000 person years for typhoid and paratyphoid respectively, with incidence being highest in in children between 2 and 4 years. Despite an apparent decline in prevalence, typhoid remains a significant burden in India, particularly among young children. Studies are required to evaluate the effectiveness of infant immunisation with conjugate typhoid vaccines.