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      Organocatalytic asymmetric C-H vinylation and arylation of N-acyl tetrahydroisoquinolines.

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          Abstract

          The first organocatalytic enantioselective oxidative C-H functionalization of N-acyl tetrahydroisoquinolines with vinyl and aryl boronates promoted by a chiral Brønsted acid is described. This metal-free process tolerates a wide range of electronically varied N-acyl tetrahydroisoquinolines and structurally diverse boronates with good to excellent enantioselectivities.

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          Author and article information

          Journal
          Org. Lett.
          Organic letters
          American Chemical Society (ACS)
          1523-7052
          1523-7052
          May 15 2015
          : 17
          : 10
          Affiliations
          [1 ] Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
          Article
          10.1021/acs.orglett.5b00909
          25941891
          b691df15-fde1-43f9-b2a3-d9bf160e812a
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