24
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Recent insights into the complexity of Tank-binding kinase 1 signaling networks: the emerging role of cellular localization in the activation and substrate specificity of TBK1.

      1 , ,
      FEBS letters

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Tank-binding kinase 1 (TBK1) serves as an important component of multiple signaling pathways. While the majority of research on TBK1 has focused on its role in innate immunity, critical functions for TBK1 in autophagy and cancer are beginning to emerge. This review highlights recent structural and biochemical studies that provide insights into the molecular mechanism of TBK1 activation and summarizes what is known to date about TBK1 substrate selection. Growing evidence suggests that both processes rely on TBK1 subcellular localization, with a variety of adaptor proteins each directing TBK1 to discrete signaling complexes for different cellular responses. Further study of TBK1-mediated pathways will require careful consideration of TBK1 mechanisms of activation and specificity for proper dissection of these distinct signaling cascades.

          Related collections

          Author and article information

          Journal
          FEBS Lett.
          FEBS letters
          1873-3468
          0014-5793
          Apr 17 2013
          : 587
          : 8
          Affiliations
          [1 ] Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA 94080, USA.
          Article
          S0014-5793(13)00104-X
          10.1016/j.febslet.2013.01.059
          23395801
          b6953cfb-6878-4342-9ecc-a7bcf3b5e5d1
          Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
          History

          Comments

          Comment on this article