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Early administration of unfractionated heparin (UFH) after TBI reduces early in vivo
circulating leukocytes (LEU) in peri-injury penumbral brain tissue, enhancing cognitive
recovery 2 days after injury. It remains unclear how long this effect lasts and if
this is related to persistently accumulating LEU in penumbral brain tissue. We hypothesized
that UFH reduces LEU brain tissue sequestration resulting in prolonged cognitive recovery.
1Division of Traumatology, Surgical Critical Care & Emergency Surgery and 2Department
of Neurosurgery, Center for Brain Injury and Repair University of Pennsylvania Perelman
School of Medicine, Philadelphia, Pennsylvania 3Department of Emergency and Critical
Care Medicine, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan 4Sidney
Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania.
Journal ID (iso-abbrev): J Trauma Acute Care Surg
The journal of trauma and acute care surgery