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Early Heparin Administration After TBI: Prolonged Cognitive Recovery Associated With Reduced Cerebral Edema and Neutrophil Sequestration.

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      Abstract

      Early administration of unfractionated heparin (UFH) after TBI reduces early in vivo circulating leukocytes (LEU) in peri-injury penumbral brain tissue, enhancing cognitive recovery 2 days after injury. It remains unclear how long this effect lasts and if this is related to persistently accumulating LEU in penumbral brain tissue. We hypothesized that UFH reduces LEU brain tissue sequestration resulting in prolonged cognitive recovery.

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      Affiliations
      [1 ] 1Division of Traumatology, Surgical Critical Care & Emergency Surgery and 2Department of Neurosurgery, Center for Brain Injury and Repair University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 3Department of Emergency and Critical Care Medicine, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan 4Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania.
      Journal
      J Trauma Acute Care Surg
      The journal of trauma and acute care surgery
      Ovid Technologies (Wolters Kluwer Health)
      2163-0763
      2163-0755
      May 22 2017
      28538627 10.1097/TA.0000000000001590

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