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      Effect of Rat Stalk Median Eminence Extracts on Rat GH Secretion In vivo

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      Hormone Research in Paediatrics

      S. Karger AG

      Rat SME, GH secretion, Estradiol

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          Estradiol (0.2 µg), injected subcutaneously for 10 days to adult male rats, increased plasma growth hormone (GH) levels as compared with oil-treated controls. In estradiol-pretreated (10 days), urethane-anesthetized rats, the first as well as the second of two successive intracarotid injections, at 1-hour intervals, of one rat stalk median eminence equivalent evoked a significant rise in plasma radioimmunoassayable GH. Under the same conditions, cerebral cortex extracts (1 equivalent) induced a slight elevation whereas vasopressin (30 mU) or serotonin (200 ng) were ineffective. These results indicate that estrogenprimed, urethane-anesthetized rats can be used to demonstrate GH-releasing activity in rat SME extracts.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 7
          : 4-5
          : 274-279
          Centre de Recherche Pédiatrique, Hôpital Sainte-Justine, Montréal, Qué.
          178738 Horm Res 1976;7:274–279
          © 1976 S. Karger AG, Basel

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          Pages: 6


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