0
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Patient‐reported quality of life in adolescents and young adults with cancer who received radiation therapy

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          Radiation therapy (RT) is a common treatment for adolescents and young adults (AYAs, 15–39 years old) with cancer; however, it may cause toxicities that affect health‐related quality‐of‐life (HRQOL). Thus, we assessed HRQOL in AYAs before, during, and after RT.

          Methods

          We identified 265 AYAs who completed HRQOL PROMIS® surveys before ( n = 87), during ( n = 84), or after ( n = 94) RT. Higher PROMIS® score represents more of the concept. Mean scores were compared to the general US population and minimally important differences (MIDs) were used to evaluate the impact of cancer on HRQOL. Linear regression modeling was used to evaluate the effect of clinical and demographic factors on PROMIS scores.

          Results

          Median [IQR] age was 26 [20–31] years. Cancer types varied; most had sarcoma (26%) or CNS malignancy (23%). Compared to the general US population, the before RT cohort had worse anxiety (mean score 55.2 vs. 50, MID 3, p < 0.001) and the during RT cohort had worse global physical health (mean score 44.9 vs. 50, MID 5, p < 0.001). In the during RT cohort, patients with regional/distant disease had significantly worse pain ( B = 15.94, p < 0.01) and fatigue ( B = 14.20, p = 0.01) than patients with localized disease. In the after RT cohort, adolescents (15–18 years) and young adults (26–39 years) had worse global physical health ( B = ‐6.87, p < 0.01, and B = ‐7.87, p < 0.01, respectively) and global mental health ( B = ‐6.74, p < 0.01, and B = ‐5.67, p = 0.01, respectively) than emerging adults (19–25 years).

          Conclusions

          AYAs with cancer receiving RT experience impairments in various domains of HRQOL. Advanced cancer stage may contribute to poorer short‐term HRQOL and developmental stage may contribute to differing long‐term HRQOL.

          Related collections

          Most cited references41

          • Record: found
          • Abstract: not found
          • Article: not found

          Emerging adulthood: A theory of development from the late teens through the twenties.

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation.

            A number of studies have computed the minimally important difference (MID) for health-related quality of life instruments. To determine whether there is consistency in the magnitude of MID estimates from different instruments. We conducted a systematic review of the literature to identify studies that computed an MID and contained sufficient information to compute an effect size (ES). Thirty-eight studies fulfilled the criteria, resulting in 62 ESs. For all but 6 studies, the MID estimates were close to one half a SD (mean = 0.495, SD = 0.155). There was no consistent relationship with factors such as disease-specific or generic instrument or the number of response options. Negative changes were not associated with larger ESs. Population-based estimation procedures and brief follow-up were associated with smaller ESs, and acute conditions with larger ESs. An explanation for this consistency is that research in psychology has shown that the limit of people's ability to discriminate over a wide range of tasks is approximately 1 part in 7, which is very close to half a SD. In most circumstances, the threshold of discrimination for changes in health-related quality of life for chronic diseases appears to be approximately half a SD.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Overall Survival Results of a Trial Assessing Patient-Reported Outcomes for Symptom Monitoring During Routine Cancer Treatment.

                Bookmark

                Author and article information

                Contributors
                mroth1@mdanderson.org
                Journal
                Cancer Med
                Cancer Med
                10.1002/(ISSN)2045-7634
                CAM4
                Cancer Medicine
                John Wiley and Sons Inc. (Hoboken )
                2045-7634
                18 May 2023
                July 2023
                : 12
                : 13 ( doiID: 10.1002/cam4.v12.13 )
                : 14157-14170
                Affiliations
                [ 1 ] Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USA
                [ 2 ] Department of Population Health Sciences, Department of Pediatrics, Center for Health Measurement Duke University School of Medicine Durham North Carolina USA
                [ 3 ] Department of Social Sciences and Health Policy Wake Forest University Winston‐Salem North Carolina USA
                [ 4 ] Institution of Health System Science, Northwell Health Manhasset New York USA
                [ 5 ] Department of Pediatrics The University of Texas MD Anderson Cancer Center Houston Texas USA
                [ 6 ] Department of Sarcoma Medical Oncology The University of Texas MD Anderson Cancer Center Houston Texas USA
                [ 7 ] Department of Behavioral Science The University of Texas MD Anderson Cancer Center Houston Texas USA
                Author notes
                [*] [* ] Correspondence

                Michael Roth, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

                Email: mroth1@ 123456mdanderson.org

                Author information
                https://orcid.org/0000-0003-0314-6972
                https://orcid.org/0000-0002-6709-8714
                https://orcid.org/0000-0003-2317-4006
                https://orcid.org/0000-0003-1131-8359
                https://orcid.org/0000-0001-8932-8560
                Article
                CAM46082 CAM4-2022-12-5470.R2
                10.1002/cam4.6082
                10358202
                37199075
                b6ac51f6-08d8-49e8-b4dc-33e0b79e8849
                © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 24 April 2023
                : 09 December 2022
                : 04 May 2023
                Page count
                Figures: 2, Tables: 4, Pages: 14, Words: 6263
                Funding
                Funded by: NIH Cancer Center Support
                Award ID: P30 CA016672
                Categories
                Research Article
                RESEARCH ARTICLES
                Clinical Cancer Research
                Custom metadata
                2.0
                July 2023
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.3.2 mode:remove_FC converted:20.07.2023

                Oncology & Radiotherapy
                adolescents and young adults,cancer,health‐related quality of life,patient‐reported outcomes,radiation therapy

                Comments

                Comment on this article