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      Drug allergy: an updated practice parameter.

      Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

      Adrenal Cortex Hormones, adverse effects, Anti-Bacterial Agents, Anti-Inflammatory Agents, Non-Steroidal, Antibodies, Monoclonal, Antineoplastic Agents, Desensitization, Immunologic, Diagnosis, Differential, Disease Susceptibility, Drug Hypersensitivity, classification, diagnosis, drug therapy, immunology, physiopathology, Drug-Related Side Effects and Adverse Reactions, Evidence-Based Medicine, Humans, Immune Tolerance, United States

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          Abstract

          Adverse drug reactions (ADRs) result in major health problems in the United States in both the inpatient and outpatient setting. ADRs are broadly categorized into predictable (type A and unpredictable (type B) reactions. Predictable reactions are usually dose dependent, are related to the known pharmacologic actions of the drug, and occur in otherwise healthy individuals, They are estimated to comprise approximately 80% of all ADRs. Unpredictable are generally dose independent, are unrelated to the pharmacologic actions of the drug, and occur only in susceptible individuals. Unpredictable reactions are subdivided into drug intolerance, drug idiosyncrasy, drug allergy, and pseudoallergic reactions. Both type A and B reactions may be influenced by genetic predisposition of the patient

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          Journal
          20934625
          10.1016/j.anai.2010.08.002

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