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      Same-Day Bilateral Intravitreal Dexamethasone Implants for the Treatment of Diabetic Macular Edema


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          Introduction: The aim of this study was to evaluate the outcomes and complications associated with the use of same-day bilateral intravitreal dexamethasone (DEX) implants for the treatment of diabetic macular edema (DME). Methods: This retrospective analysis of an open-label, multicenter, consecutive case series included 130 eyes of 65 patients with bilateral DME who were treated with intravitreal DEX implants. The patients were divided into two groups: a control group (comprising 40 eyes treated with an alternating unilateral regimen) and a study group (comprising 90 eyes treated with concomitant bilateral DEX implants). All patients were followed up monthly after implantation. The changes in best-corrected visual acuity (BCVA) and central retinal thickness (CRT) from baseline to sixth month after implantation, and ocular adverse effects such as intraocular pressure, cataract, and tolerability of bilateral implantation were reviewed. The primary endpoint was to assess the safety of the same-day bilateral treatment protocol. The secondary endpoints focused on evaluating the functional and anatomical changes associated with bilateral simultaneous or alternating implantations. Results: At 6 months after implantation, mean BCVA increased and CRT decreased in both groups. Moreover, no serious ocular adverse effects were observed. In addition, no differences were observed between the two groups in the number of patients who required extra follow-up visits or the number of extra visits made in addition to the treatment schedule. Conclusions: Same-day bilateral intravitreal DEX implants are associated with a low complication rate and are well tolerated by patients. This safe practice may optimize efficiency and reduce the burden on both the health-care system and patients, when used to treat bilateral DME.

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          Author and article information

          S. Karger AG
          November 2023
          08 August 2023
          : 246
          : 3-4
          : 238-244
          [_a] aDepartment of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
          [_b] bDepartment of Ophthalmology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
          [_c] cDepartment of Ophthalmology, Taipei City Hospital, Renai Branch, Taipei, Taiwan
          [_d] dDepartment of Special Education, University of Taipei, Taipei, Taiwan
          [_e] eDepartment of Ophthalmology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
          [_f] fDepartment of Ophthalmology, Cheng Hsin General Hospital, Taipei, Taiwan
          [_g] gInstitue of Public Health, National Taiwan University, Taipei, Taiwan
          [_h] hDepartment of Life Science, Institute of Molecular Biology, Institute of Biomedical Science, National Chung Cheng University, Chiayi, Taiwan
          [_i] iDepartment of Ophthalmology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
          [_j] jGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
          [_k] kDepartment of Life Science, Fu Jen Catholic University, New Taipei City, Taiwan
          [_l] lDepartment of Ophthalmology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan
          [_m] mSchool of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan
          [_n] nGraduate Institute of Business Administration, Fu Jen Catholic University, New Taipei City, Taiwan
          Author notes
          *Yu-Chien Chung, cherie.cyc@gmail.com
          532056 Ophthalmologica 2023;246:238–244
          © 2023 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.

          : 18 February 2023
          : 03 July 2023
          Page count
          Tables: 3, Pages: 7
          This study was supported by YEN TJING LING MEDICAL FOUNDATION (CI-112-23) and Taipei Veterans General Hospital (V112C-195).
          Research Article

          Bilateral intravitreal implants,Dexamethasone,Diabetic macular edema,Same-day bilateral treatment


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