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      Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?

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      Brain Research Reviews

      Elsevier BV

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          Most cited references 209

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          Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin

           C Rivier,  J Rivier,  J Spiess (1981)
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            Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients.

            The possibility that hypersecretion of corticotropin-releasing factor (CRF) contributes to the hyperactivity of the hypothalamo-pituitary-adrenal axis observed in patients with major depression was investigated by measuring the concentration of this peptide in cerebrospinal fluid of normal healthy volunteers and in drug-free patients with DSM-III diagnoses of major depression, schizophrenia, or dementia. When compared to the controls and the other diagnostic groups, the patients with major depression showed significantly increased cerebrospinal fluid concentrations of CRF-like immunoreactivity; in 11 of the 23 depressed patients this immunoreactivity was greater than the highest value in the normal controls. These findings are concordant with the hypothesis that CRF hypersecretion is, at least in part, responsible for the hyperactivity of the hypothalamo-pituitary-adrenal axis characteristic of major depression.
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              Species-specific defense reactions and avoidance learning.

               Robert Bolles (1970)
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                Author and article information

                Journal
                Brain Research Reviews
                Brain Research Reviews
                Elsevier BV
                01650173
                May 1990
                May 1990
                : 15
                : 2
                : 71-100
                Article
                10.1016/0165-0173(90)90012-D
                © 1990

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