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      Muscle, Bone, and Fat Crosstalk: the Biological Role of Myokines, Osteokines, and Adipokines

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          Abstract

          Skeletal muscle and bone are connected anatomically and physiologically, and play a crucial role in human locomotion and metabolism. Historically, the coupling between muscle and bone has been viewed in light of mechanotransduction, which dictates that the mechanical forces applied to muscle are transmitted to the skeleton to initiate bone formation. However, these organs also communicate through the endocrine system, orchestrated by a family of cytokines namely myokines (derived from myocytes) and osteokines (derived from bone cells). A third player in this biochemical crosstalk is adipose tissue and the secretion of adipokines (derived from adipocytes). In this review, we discuss the bidirectional effects of myokines and osteokines on muscle and bone metabolism, and the impact of adipokines on both of these secretory organs.

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          Author and article information

          Journal
          Current Osteoporosis Reports
          Curr Osteoporos Rep
          Springer Science and Business Media LLC
          1544-1873
          1544-2241
          June 12 2020
          Article
          10.1007/s11914-020-00599-y
          32529456
          b6cccba1-2d20-48e6-8c68-e3ad7439e760
          © 2020

          http://www.springer.com/tdm

          http://www.springer.com/tdm

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