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Impact of CYP1A1 Polymorphisms on Susceptibility to Chronic Obstructive Pulmonary Disease: A Meta-Analysis

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      Objective. Several studies have evaluated the association between CYP1A1 polymorphisms and the susceptibility of chronic obstructive pulmonary disease (COPD) with inconclusive results. We performed the first comprehensive meta-analysis to summarize the association between CYP1A1 polymorphisms and COPD risk. Method. A systematic literature search was conducted (up to April 2015) in five online databases: PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), WeiPu, and WanFang databases. The strength of association was calculated by odds ratio (OR) and corresponding 95% confidence interval (CI). Results. Seven case-control studies with 1050 cases and 1202 controls were included. Our study suggested a significant association between the MspI polymorphism and COPD risk (CC versus TC + TT: OR = 1.57, CI: 1.09–2.26, P = 0.02; CC versus TT: OR = 1.73, CI: 1.18–2.55, P = 0.005). For the Ile/Val polymorphism, a significant association with COPD risk was observed (GG versus AG + AA: OR = 2.75, CI: 1.29–5.84, P = 0.009; GG versus AA: OR = 3.23, CI: 1.50–6.93, P = 0.003; AG versus AA: OR = 1.39, CI: 1.01–1.90, P = 0.04). Subgroup analysis indicated a significant association between the MspI variation and COPD risk among Asians (CC versus TC + TT: OR = 1.70, CI: 1.06–2.71, P = 0.03; CC versus TT: OR = 1.84, CI: 1.11–3.06, P = 0.02). Conclusion. The MspI and Ile/Val polymorphisms might alter the susceptibility of COPD, and MspI polymorphism might play a role in COPD risk among Asian population.

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            Author and article information

            1Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
            2West China School of Medicine/West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
            Author notes

            Academic Editor: Jill E. Larsen

            Biomed Res Int
            Biomed Res Int
            BioMed Research International
            Hindawi Publishing Corporation
            3 September 2015
            : 2015
            Copyright © 2015 Cheng-Di Wang et al.

            This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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