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      Prenylated stilbenes and flavonoids from the leaves of Cajanus cajan

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          Abstract

          Three new prenylated stilbenes, named as cajanusins A-C ( 1–3), and one new natural product cajanusin D ( 4), along with six known derivatives ( 5–10) were isolated from the leaves of Cajanus cajan. Their structures were fully elucidated by means of extensive spectroscopic methods and comparison with data in the reported literatures. The new compounds of 1 and 2 were evaluated for in vitro cytotoxic activities against a panel of human cancer cell lines.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 May 2019
          : 17
          : 5
          : 381-386
          Affiliations
          1 Laboratory of Chinese Herbal Drug Discovery, Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
          2 Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
          3 Guangdong Institute of Microbiology, Guangzhou 510070, China
          Author notes
          *Corresponding author: TAN Hai-Bo, Tel/Fax: 86-20-37252958, E-mail: tan-haibo@ 123456scbg.ac.cn ; HU Ying-Jie, Tel: 86-20-36585143, E-mail: yjhu01@ 123456126.com

          ΔThese authors contributed equally to this work.

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(19)30044-5
          10.1016/S1875-5364(19)30044-5
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 81773602
          Award ID: 81502949
          Funded by: Natural Science Foundation of Guangdong Province
          Award ID: 2016A030313149
          Award ID: 2016A020217015
          Funded by: Innovative Team Project of GZUCM
          Award ID: 2016KYTD04
          Funded by: Pearl River Science and Technology New Star Fund of Guangzhou
          Award ID: 201605120849569
          Funded by: Guangdong Special Support Program
          Award ID: 2017TQ04R599
          This work was supported by the National Natural Science Foundation of China (Nos. 81773602 and 81502949), the Natural Science Foundation of Guangdong Province (Nos. 2016A030313149 and 2016A020217015), the Innovative Team Project of GZUCM (No. 2016KYTD04), Pearl River Science and Technology New Star Fund of Guangzhou (No. 201605120849569), Guangdong Special Support Program (No. 2017TQ04R599), and the Foundation of Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences.

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