A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289

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Abstract

Objective

This study aimed to investigate the tumor circular RNA_0018289 (circ_0018289) expression and its correlation with clinical characteristics as well as survival profiles in cervical cancer patients.

Methods

A hundred and ninety‐two cervical cancer patients who received surgical resection were recruited in this prospective study. Tumor tissue and paired adjacent tissue were obtained during the surgery, in which circ_0018289 expression was detected by reverse transcription quantitative polymerase chain reaction. Disease‐free survival (DFS) and overall survival (OS) were recorded.

Results

Circ_0018289 expression was upregulated in tumor tissue compared with paired adjacent tissue ( P < .001), and receiver operative characteristic curve disclosed its good value for separating tumor tissue from adjacent tissue with an area under curve of 0.907 (95% CI: 0.879‐0.935). Additionally, tumor circ_0018289 expression was positively associated with tumor size ( P = .009), lymph node metastasis ( P = .005) and Federation International of Gynecology and Obstetrics stage ( P = .005). The DFS ( P = .005) and OS ( P = .015) were both worse in patients with circ_0018289 high expression compared to patients with circ_0018289 low expression. Meanwhile, in patients with circ_0018289 high expression, DFS and OS were the longest in patients with high+ expression followed by patients with high++ expression, and the shortest in patients with high+++ expression. Moreover, circ_0018289 high expression could independently predict worse DFS in the total cervical cancer patients ( P = .042).

Conclusion

Circ_0018289 could serve as a potential disease monitoring and prognostic biomarker in cervical cancer patients.

Related collections

Most cited references 10

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Human Papillomavirus Infection and Cervical Cancer: Epidemiology, Screening, and Vaccination—Review of Current Perspectives

Chee Kai Chan, Gulzhanat Aimagambetova, Talshyn Ukybassova … (2019)

Viral infections contribute as a cause of 15–20% of all human cancers. Infection by oncogenic viruses can promote different stages of carcinogenesis. Among many types of HPV, around 15 are linked to cancer. In spite of effective screening methods, cervical cancer continues to be a major public health problem. There are wide differences in cervical cancer incidence and mortality by geographic region. In addition, the age-specific HPV prevalence varies widely across different populations and showed two peaks of HPV positivity in younger and older women. There have been many studies worldwide on the epidemiology of HPV infection and oncogenic properties due to different HPV genotypes. However, there are still many countries where the population-based prevalence has not yet been identified. Moreover, cervical cancer screening strategies are different between countries. Organized cervical screening programs are potentially more effective than opportunistic screening programs. Nevertheless, screening programs have consistently been associated with a reduction in cervical cancer incidence and mortality. Developed countries have achieved such reduced incidence and mortality from cervical cancer over the past 40 years. This is largely due to the implementation of organized cytological screening and vaccination programs. HPV vaccines are very effective at preventing infection and diseases related to the vaccine-specific genotypes in women with no evidence of past or current HPV infection. In spite of the successful implementation of the HPV vaccination program in many countries all over the world, problems related to HPV prevention and treatment of the related diseases will continue to persist in developing and underdeveloped countries.

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Human papillomavirus in cervical cancer and oropharyngeal cancer: One cause, two diseases.

Tara A. Berman, John T. Schiller (2017)

Human papillomavirus (HPV) causes greater than 5% of cancers worldwide, including all cervical cancers and an alarmingly increasing proportion of oropharyngeal cancers (OPCs). Despite markedly reduced cervical cancer incidence in industrialized nations with organized screening programs, cervical cancer remains the second most common cause of death from cancer in women worldwide, as developing countries lack resources for universal, high-quality screening. In the United States, HPV-related OPC is only 1 of 5 cancers with a rising incidence since 1975 and now has taken over the cervix as the most common site of HPV-related cancer. Similar trends follow throughout North America and Europe. The need for early detection and prevention is paramount. Despite the common etiologic role of HPV in the development of cervical cancer and HPV-associated OPC, great disparity exists between incidence, screening modalities (or lack thereof), treatment, and prevention in these 2 very distinct cohorts. These differences in cervical cancer and HPV-associated OPC and their impact are discussed here. Cancer 2017;123:2219-2229. © 2017 American Cancer Society.

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Pathogenic role of exosomes and microRNAs in HPV‐mediated inflammation and cervical cancer: A review

Javid Sadri Nahand, Mohsen Moghoofei, Arash Salmaninejad … (2019)

Cervical cancer (CC) is the fourth most common cause of cancer death in women. The most important risk factor for the development of CC is cervical infection with human papilloma virus (HPV). Inflammation is a protective strategy that is triggered by the host against pathogens such as viral infections that acts rapidly to activate the innate immune response. Inflammation is beneficial if it is brief and well-controlled, however, if the inflammation is excessive or it becomes of chronic duration, it can produce detrimental effects. HPV proteins are involved, both directly and indirectly, in the development of chronic inflammation, which is a causal factor in the development of CC. However, other factors may also have a potential role in stimulating chronic inflammation. MicroRNAs (miRNAs) (a class of non-coding RNAs) are strong regulators of gene expression. They have emerged as key players in several biological processes, including inflammatory pathways. Abnormal expression of miRNAs may be linked to the induction of inflammation that occurs in CC. Exosomes are a subset of extracellular vesicles shed by almost all types of cells, which can function as cargo transfer vehicles. Exosomes contain proteins and genetic material (including miRNAs) derived from their parent cells and can potentially affect recipient cells. Exosomes have recently been recognized to be involved in inflammatory processes and can also affect the immune response. In this review, we discuss the role of HPV proteins, miRNAs and exosomes in the inflammation associated with CC.

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Author and article information

Contributors

Zhen Zeng:

ORCID: https://orcid.org/0000-0003-3566-5195

zhencu291480@163.com

Journal

Journal ID (nlm-ta): J Clin Lab Anal

Journal ID (iso-abbrev): J. Clin. Lab. Anal

Journal ID (doi): 10.1002/(ISSN)1098-2825

Journal ID (publisher-id): JCLA

Title: Journal of Clinical Laboratory Analysis

Publisher: John Wiley and Sons Inc. (Hoboken )

ISSN (Print): 0887-8013

ISSN (Electronic): 1098-2825

Publication date (Electronic): 22 April 2020

Publication date Collection: August 2020

Volume: 34

Issue: 8 ( doiID: 10.1002/jcla.v34.8 )

Electronic Location Identifier: e23340

Affiliations

[ ¹ ] Department of Gynecology and Obstetrics The Central Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology Wuhan China

Author notes

[*] [* ] Correspondence

Zhen Zeng, Department of Gynecology and Obstetrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 26 Shengli Street, Wuhan 430014, China.

Email: zhencu291480@ 123456163.com

Author information

Zhen Zeng https://orcid.org/0000-0003-3566-5195

Article

Publisher ID: JCLA23340

DOI: 10.1002/jcla.23340

PMC ID: 7439420

PubMed ID: 32320103

SO-VID: b6f80b49-a258-45b2-ae87-3e16bae81a45

License:

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

History

Date received : 14 January 2020

Date revision received : 10 March 2020

Date accepted : 27 March 2020

Page count

Figures: 4, Tables: 4, Pages: 8, Words: 5091

Custom metadata

source-schema-version-number 2.0

cover-date August 2020

details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.7 mode:remove_FC converted:20.08.2020

ScienceOpen disciplines: Clinical chemistry

Keywords: cervical cancer,circ_0018289,clinical characteristics,survival,tumor tissue

Data availability: