Use of the forced-oscillation technique to estimate spirometry values

Abstract

Purpose

Spirometry is sometimes difficult to perform in elderly patients and in those with severe respiratory distress. The forced-oscillation technique (FOT) is a simple and noninvasive method of measuring respiratory impedance. The aim of this study was to determine if FOT data reflect spirometric indices.

Patients and methods

Patients underwent both FOT and spirometry procedures prior to inclusion in development (n=1,089) and validation (n=552) studies. Multivariate linear regression analysis was performed to identify FOT parameters predictive of vital capacity (VC), forced VC (FVC), and forced expiratory volume in 1 second (FEV ₁). A regression equation was used to calculate estimated VC, FVC, and FEV ₁. We then determined whether the estimated data reflected spirometric indices. Agreement between actual and estimated spirometry data was assessed by Bland–Altman analysis.

Results

Significant correlations were observed between actual and estimated VC, FVC, and FEV ₁ values (all r>0.8 and P<0.001). These results were deemed robust by a separate validation study (all r>0.8 and P<0.001). Bias between the actual data and estimated data for VC, FVC, and FEV ₁ in the development study was 0.007 L (95% limits of agreement [LOA] 0.907 and −0.893 L), −0.064 L (95% LOA 0.843 and −0.971 L), and −0.039 L (95% LOA 0.735 and −0.814 L), respectively. On the other hand, bias between the actual data and estimated data for VC, FVC, and FEV ₁ in the validation study was −0.201 L (95% LOA 0.62 and −1.022 L), −0.262 L (95% LOA 0.582 and −1.106 L), and −0.174 L (95% LOA 0.576 and −0.923 L), respectively, suggesting that the estimated data in the validation study did not have high accuracy.

Conclusion

Further studies are needed to generate more accurate regression equations for spirometric indices based on FOT measurements.

Journal

Journal ID (nlm-ta): Int J Chron Obstruct Pulmon Dis

Journal ID (iso-abbrev): Int J Chron Obstruct Pulmon Dis

Journal ID (publisher-id): International Journal of COPD

Title: International Journal of Chronic Obstructive Pulmonary Disease

Publisher: Dove Medical Press

ISSN (Print): 1176-9106

ISSN (Electronic): 1178-2005

Publication date Collection: 2017

Publication date (Electronic): 03 October 2017

Volume: 12

Pages: 2859-2868

Affiliations

[1 ]Department of Cardiology, Pulmonology, Hypertension, and Nephrology

[2 ]Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Toon

[3 ]Department of Internal Medicine, Sumitomo Besshi Hospital, Niihama, Japan

Author notes

Correspondence: Seigo Miyoshi, Department of Cardiology, Pulmonology, Hypertension, and Nephrology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan, Tel [phone], Fax [phone], Email seigom@ 123456m.ehime-u.ac.jp

Article

Publisher ID: copd-12-2859

DOI: 10.2147/COPD.S143721

PMC ID: 5633305

Copyright statement: © 2017 Yamamoto et al. This work is published and licensed by Dove Medical Press Limited

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Categories

Subject: Original Research