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      An evidence-based evaluation on the use of platelet rich plasma in orthopedics – a review of the literature

      review-article
      1 , * , 2 , 2
      SICOT-J
      EDP Sciences
      Platelet rich plasma, Orthobiologics, Evidence-based medicine, Review

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          Abstract

          Within orthopedics, the use of platelet-rich plasma (PRP) has been rapidly increasing in popularity, however, its true effectiveness has yet to be fully established. Several studies find that injecting PRP to the site of injury does not provide any significant benefit with respect to clinical outcomes; however, many others report the contrary. Due to the conflicting evidence and multiple meta-analyses conducted on the topic, a literature review of high-quality evidence on the use of PRP for common orthopaedic conditions was performed. Thus far, the evidence appears to suggest that PRP may provide some benefit in patients who present with knee osteoarthritis or lateral epicondylitis. On the other hand, evidence appears to be inconsistent or shows a minimal benefit for PRP usage in rotator cuff repair, patellar and Achilles tendinopathies, hamstring injuries, anterior cruciate ligament (ACL) repair, and medial epicondylitis. There is limited confidence in the conclusions from the published meta-analyses due to issues with statistical pooling, and limited subgroup analyses exploring the substantial heterogeneity across studies. Evidence-based clinicians considering the use of PRP in their patients with musculoskeletal injuries should be weary that the literature appears to be inconsistent and thus far, inconclusive.

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          Most cited references60

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          Platelet-rich plasma: evidence to support its use.

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            Platelet-rich plasma (PRP): what is PRP and what is not PRP?

            R Marx (2001)
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              Platelet-Rich Plasma (PRP): What Is PRP and What Is Not PRP?

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                Author and article information

                Journal
                SICOT J
                SICOT J
                sicotj
                SICOT-J
                EDP Sciences
                2426-8887
                2017
                09 October 2017
                : 3
                : ( publisher-idID: sicotj/2017/01 )
                : 57
                Affiliations
                [1 ] Central Michigan University College of Medicine, CMED Building 1280 S. East Campus St. Mt. Pleasant MI 48859 USA
                [2 ] Division of Orthopaedic Surgery, Department of Surgery, McMaster University & Centre for Evidence Based Orthopaedics 293 Wellington Street North, Suite 110 Hamilton Ontario L8L 8E7 Canada
                Author notes
                [* ]Corresponding author: nasir.hussain@ 123456cmich.edu
                Article
                sicotj170038 10.1051/sicotj/2017036
                10.1051/sicotj/2017036
                5632954
                28990574
                b7435f1c-3f89-4f19-ab4e-16c72272c627
                © The Authors, published by EDP Sciences, 2017

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 14 March 2017
                : 06 June 2017
                Page count
                Figures: 1, Tables: 1, Equations: 0, References: 55, Pages: 7
                Categories
                Shoulder
                Special Issue: "Orthobiologics: role of platelet-rich plasma in orthopaedic clinical practice" Guest Editor: Vijay D. Shetty
                Review Article

                platelet rich plasma,orthobiologics,evidence-based medicine,review

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