Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation.

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Abstract

Liver fibrosis, an important health concern associated to chronic liver injury that provides a permissive environment for cancer development, is characterized by accumulation of extracellular matrix components mainly derived from activated hepatic stellate cells (HSCs). Axl, a receptor tyrosine kinase and its ligand Gas6, are involved in cell differentiation, immune response and carcinogenesis.

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Journal ID (iso-abbrev): J. Hepatol.

Title: Journal of hepatology

Publisher: Elsevier BV

ISSN (Electronic): 1600-0641

ISSN (Print): 0168-8278

Publication date (Electronic): Sep 2015

Volume: 63

Issue: 3

Affiliations

[1 ] Liver Unit, Hospital Clinic, IDIBAPS-CIBEK, CIBEREHD, Barcelona, Catalonia, Spain; Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Catalonia, Spain.

[2 ] Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

[3 ] Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Catalonia, Spain.

[4 ] Liver Unit, Hospital Clinic, IDIBAPS-CIBEK, CIBEREHD, Barcelona, Catalonia, Spain.

[5 ] Liver Unit, Hospital Clinic, IDIBAPS-CIBEK, CIBEREHD, Barcelona, Catalonia, Spain; Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Catalonia, Spain; Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.

[6 ] Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Catalonia, Spain. Electronic address: pablo.garcia@iibb.csic.es.

[7 ] Liver Unit, Hospital Clinic, IDIBAPS-CIBEK, CIBEREHD, Barcelona, Catalonia, Spain; Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Catalonia, Spain. Electronic address: amorales@clinic.ub.es.

Article

Publisher Item ID: S0168-8278(15)00296-2 Mid ID: NIHMS683375

DOI: 10.1016/j.jhep.2015.04.013

PMC ID: 4543529

PubMed ID: 25908269

SO-VID: b76a5bb2-15ac-4ce1-a012-ab7e417897a2

History

Keywords: Chronic liver patients,Experimental fibrosis,Gas6/Axl serum levels,HSC activation,TAM receptors

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Keywords: Chronic liver patients, Experimental fibrosis, Gas6/Axl serum levels, HSC activation, TAM receptors

Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation.

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