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      Cardiac Sympathetic Nervous Activity during Myocardial Ischemia, Reperf usion and Ventricular Fibrillation in the Dog - Effects of Intravenous Lidocaine

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          In 12 open-chest dogs, cardiac sympathetic nervous activity (CSNA) was recorded before and after occlusion of the left anterior descending coronary artery as well as during reperfusion and ventricular fibrillation (VF). In 7 control animals, CSNA did not significantly differ from preocclusion levels when determined 20 min after occlusion (+3.5 ± 1.5%, mean ± SEM) and up to 15 min following reperfusion (+1.5 ± 0.6%). However, VF was associated with a potential increase in CSNA by 106 ± 15.5%(p < 0.001). The effect of lidocaine (6 mg/kg) on cardiac sympathetic tone was examined in 5 additional animals. Lidocaine reduced control CSNA by 23 ± 4.7% (p < 0.001); subsequent ischemia and reperfusion did not substantially change the level of preocclusion activity. CSNA decreased significantly also during VF (52 ± 4.2%, p < 0.001). In conclusion, efferent CSNA was slightly altered in the course of acute myocardial ischemia and reperfusion, but significantly increased during VF. Lidocaine produced marked attenuation of CSNA in anesthetized dogs.

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          Author and article information

          S. Karger AG
          12 November 2008
          : 80
          : 3-4
          : 196-204
          Departments of aCardiology and bPhysiology I, University of Heidelberg, FRG
          175003 Cardiology 1992;80:196–204
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 9
          Arrhythmias, Electrophysiology and Electrocardiography


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